多模态融合技术三维重建岩上静脉  

Three-dimensional reconstruction of superior petrosal vein by multi-modal fusion technology

作　　者：吴世源 何浩强[2] 陈正和[3] 牟永告[3] 李严兵 黄文华[1,4] 钟世镇 Wu Shiyuan;He Haoqiang;Chen Zhenghe;Mou Yonggao;Li Yanbing;Huang Wenhua;Zhong Shizhen(Guangdong Engineering Research Center for Translation of Medical 3D Printing Application,Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics,National Key Discipline of Human Anatomy,School of Basic Medical Sciences,Southern Medical University,Guangzhou 510515,China;Department of Radiology,Sun Yat-sen University Cancer Center,Guangzhou 510000,China;Department of Neurosurgery/Neuro-oncology,Sun Yat-sen University Cancer Center,State Key Laboratory of Oncology in South China,Collaborative Innovation Center for Cancer Medicine,Guangzhou 510000,China;Guangdong Medical Innovation Platform for Translation of 3D Printing Application,The Third Affiliated Hospital of Southern Medical University,Guangzhou 510000,China)

机构地区：[1]南方医科大学基础医学院人体解剖学国家重点学科,广东省数字医学与生物力学重点实验室,广东省医学3D打印应用转化工程技术研究中心,广州510515 [2]中山大学肿瘤防治中心影像科,广州510000 [3]中山大学肿瘤防治中心神经外科/神经肿瘤科,华南肿瘤学国家重点实验室,癌症医学协同创新中心,广州510000 [4]南方医科大学第三附属医院,广东省医学3D打印应用转化创新平台,广州510000

出　　处：《中国临床解剖学杂志》2023年第3期270-276,共7页Chinese Journal of Clinical Anatomy

基　　金：国家重点研发计划(2017YFC1103400);广东省科技计划项目(2016B090917001);广东省科技计划项目(2018B090944002);深圳市医疗卫生“三名工程”高层次医学团队(SZSM201612019)。

摘　　要：目的为了更客观、更个性化地体现岩上静脉(Superior petrosal vein,SPV)及其毗邻骨性结构的形态学特点,应用对比增强磁共振血管成像(Contrast enhanced magnetic resonance angiography,CEMRA)和电子计算机断层扫描(CT)相结合的多模态融合技术三维重建岩上静脉复合体及其周围颅骨的正常解剖结构,为解剖学研究和临床手术提供新的参考。方法通过对造影剂浓度、造影剂推注速度、开始扫描时间等的调整,扫描得到的3D CEMRA经过图像处理工作站MIP后处理软件判断岩上静脉复合体(SPVC)显影成功。3D CEMRA与3D-CT的原始数据共同导入3Dslicer软件,通过图像配准、阈值分割、结构修剪和数据打包保存,最后把这两种模态的打包数据共同导入并同时3D融合显现。运用3Dslicer软件的测量模块对相关解剖参数进行测量。结果①得到造影精度分别为乙状窦、岩上窦(Superior petrosal sinus,SPS)、SPV、SPV属支的相关造影参数,但是成功率不够稳定;②通过对头部CEMRA和头颅CT的DICOM数据的三维重建,得到SPV及其属支、SPS、乙状窦、横窦和海绵窦等静脉结构,内耳道、岩上窦沟和横窦沟等颅底特别是岩斜区附近的骨性解剖标志;③多模态融合后静脉结构和骨性结构的三维融合图;④运用3Dslicer软件中的测量模块测量的测量图示。结论提示影像学与3Dslicer软件的结合可以逼真地展示多模态融合的解剖结构,为解剖形态学的研究提供了新的可能,同时也可以为临床手术提供个性化参考。Objective To reflect the morphological characteristics of SPV and its adjacent bone structures objectively,contrast enhanced magnetic resonance angiography(CEMRA)and computer tomography(CT)were used by combining with multi-modal fusion technology to reconstruct the normal anatomical structure of the superior petrosal vein complex and its surrounding skull,which providing reference for anatomical research and clinical surgery.Methods By adjusting the concentration of the contrast agent,the injection speed of the contrast agent,the start time of scanning,the scanned 3D CEMRA was judged to be developed successfully by the MIP post-processing of image processing workstation.The original data of 3D CEMRA and 3D-CT were imported into 3Dslicer software together.After image registration,threshold segmentation,structure pruning and data package storage,the packaged data of these two modalities were imported together and 3D fusion was performed at the same time.The related anatomical parameters were measured by using the module of 3Dslicer software.Results①The relevant angiographic parameters of the sigmoid sinus,superior petrosal sinus(SPS),SPV,and SPV tributary was obtained,but the success rate was not stable;②Through the three-dimensional reconstruction of the DICOM data from the head CEMRA and cranial CT,SPV and its branch,SPS,sigmoid sinus,transverse sinus and cavernous sinus,bone anatomical landmarks of skull base such as internal auditory canal,petrosal sinus groove and transverse sinus groove near the petrosal area were obtained;③Three-dimensional fusion map of venous structure and osseous structure after multi-modal fusion was obtained;④The measurement diagram was obtained by using the measurement module in the 3Dslicer software.Conclusions The combination of imaging and 3Dslicer software can realistically display the anatomical structure of multi-modal fusion,providing a new possibility for the study of anatomical morphology,and also providing personalized reference for clinical surgery.

关 键 词：岩上静脉 解剖学 神经外科 影像学 CEMRA 3Dslicer 三维重建 多模态融合 

分 类 号：R323.1[医药卫生—人体解剖和组织胚胎学]