Clinical profile,etiology,and outcome of hemophagocytic lymphohistiocytosis associated with histiocytic necrotizing lymphadenitis  

作　　者：Kuang-Guo Zhou Duan-Hao Gong Dan Peng Zhi-Qiong Wang Wei Huang 

机构地区：[1]Department of Hematology,Tongji Medical College,Tongji Hospital,Huazhong University of Science and Technology,Jiefang Road 1095#,Wuhan,430030,China [2]Department of Nuclear Medicine,Tongji Medical College,Tongji Hospital,Huazhong University of Science and Technology,Wuhan,China

出　　处：《World Journal of Pediatrics》2023年第4期406-410,共5页世界儿科杂志（英文版）

基　　金：supported by a grant from the National Natural Science Foundation of China(No.81770164).

摘　　要：Hemophagocytic lymphohistiocytosis(HLH)is a life-threatening clinical syndrome characterized by aberrantly activated macrophages and cytotoxic T cells,leading to mul-tiple organ failure[1].The main manifestations included recurrent fever,cytopenia,liver dysfunction,and sepsis-like syndrome.Physicians should be fully aware of HLH since early diagnosis and management may prevent irreversible organ failure and subsequent death.Treatment protocols,such as HLH-94 based on etoposide(VP 16),are commonly used in clinical practice,especially in familial HLH[2]and malignancy-associated HLH[3].

关 键 词：CLINICAL HISTIOCYTOSIS DIAGNOSIS 

分 类 号：R72[医药卫生—儿科]