Visible Light Promoted Direct Deuteration of Alkenes via Co(III)–H Mediated H/D Exchange  

作　　者：Zongbin Jia Sanzhong Luo 

机构地区：[1]Department of Chemistry,Center of Basic Molecular Science(CBMS),Tsinghua University,Beijing 100084

出　　处：《CCS Chemistry》2023年第5期1069-1076,共8页中国化学会会刊（英文）

基　　金：the Natural Science Foundation of China(grant nos.91956000,22031006,21861132003),Tsinghua University Initiative Scientific Research Program,and Haihe Laboratory of Sustainable Chemical Transformations for financial support.

摘　　要：We report herein a visible light-mediated direct deuteration of alkenes with D_(2)O or deuterated methanol(MeOD)using a cobaloxime as a hydrogen/deuterium(H/D)exchange catalyst.The synergistic photoredox/Co catalysis enabled facile deuterium(D)-incorporation of a variety of terminal and internal alkenes at either terminal or benzylic positions.We proposed that this process proceeded through a sequence of reversible addition-elimination reactions and fast proton exchange involving Co(III)–H,which was generated in situ by photoreduction.

关 键 词：DEUTERATION COBALOXIME hydrogen isotope exchange alkyl cobalt PHOTOREDOX 

分 类 号：O62[理学—有机化学]