Nephrolithiasis: Insights into Biomimics, Pathogenesis, and Pharmacology  

作　　者：Aishwarya Tripurasundari Devi Rajini Nagaraj Ashwini Prasad Dhananjaya Bhadrapura Lakkappa Farhan Zameer Nagendra Prasad Mysore Nagalingaswamy 

机构地区：[1]Department of Biotechnology Sri Jayachamarajendra College of Engineering,JSS Science and Technology University,JSS Research Foundation,SJCE Campus,Manasagangothri,Mysore 570006,Karnataka,India [2]Division of Microbiology,Faculty of Life Sciences,JSS University,Mysore 570015,Karnataka,India [3]Department of NanoSciences,Faculty of Engineering&Technology,Jain Global Campus,Jain Deemed-to-be University,Ramanagara 562112,Karnataka,India [4]Department of Dravyaguna Vignana,Alva’s Ayurveda Medical College,Sundari Ananda Alva Campus and ATMA Research Center(PathoGutOmic Laboratory),Vidyagiri,Moodubidire,Dakshina Kannada 574227,Karnataka,India

出　　处：《Clinical Complementary Medicine and Pharmacology》2023年第2期22-38,共17页临床补充医学和药理学（英文）

摘　　要：Background:In the last decade,a varied prevalence of lifestyle-mediated health ailments ranging from infectious disorders to non-curable diseases has been observed.Globally the stone formation(lithiasis)in human kidneys has increased the trauma and economic burden.Furthermore,affordable rapid diagnosis,clinical trials,and therapeutics have to be addressed with newer holistic approaches.Objective:The current comprehensive review attempts to study kidney stones using emerging translational,con-ventional,and non-conventional research models,which include prokaryotic and eukaryotic systems(in vitro,semi-in vivo,and in vivo).Methods:The study eligibility criteria included systematic reviews and meta-analyses to explore various lithiatic models.Further,PubMed,PubMed Central,CINAHL Plus,Scopus,Web of Science,and EMBASE were used as data sources for the current study.A Measurement Tool to Assess Systematic Reviews(AMSTAR)was used.Results:All curated literature from past 55 years(1967-2022)were considered for this review with keywords as"Experimental models for human kidney stones"AND"Nephrolithasis"AND"Urolithasis".A total of 765 abstracts were reviewed for inclusion with 414 selected for full-text review.A total of 47 studies were analyzed.Mean AMSTAR score of 6.96/11(±1.84)suggests moderate quality of the systematic reviews.Conclusion:This review will empower clinicians,veterinarians,and researchers for a better understanding of the pathogenesis,causative factors,and prevalence of nephrolithiasis and urolithiasis and their associated mech-anisms with rapid,reliable,and reproducible models.The findings of the study will aid in designing global healthcare policy and regional insurance for lithiatic disorders with effective therapeutics which will result in an increased quality of life,leading to better health and hygiene.

关 键 词：Biomarkers Lifestyle disorder Models for lithiasis NEPHRON THERAPEUTICS 

分 类 号：R96[医药卫生—药理学]