细菌疗法在肿瘤临床治疗中的进展及应用  

Advances and applications of bacteriotherapy in the clinical treatment of tumors

作　　者：花私齐 华子春 HUA Siqi;HUA Zichun(School of Biopharmacy,China Pharmaceutical University,Nanjing 211198;Changzhou High-Tech Research Institute of Nanjing University and Jiangsu Target Pharma Laboratories Inc.,Changzhou 213164,China)

机构地区：[1]中国药科大学生物药物学院,江苏南京211198 [2]常州南京大学高新技术研究院暨江苏省产业技术研究院医药生物技术研究所,江苏常州213164

出　　处：《南京医科大学学报（自然科学版）》2023年第5期589-594,共6页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金(82130106,32250016);南京市生命健康科技专项(202110016);常州市“揭榜挂帅”科技攻关项目(2022169)。

摘　　要：由于肿瘤及其微环境的复杂性,传统的癌症疗法存在严重局限,如药物响应性差、不良反应大、药物难以到达肿瘤深部、肿瘤易复发等。近年来,细菌介导的癌症免疫疗法以其独特的优势正引起人们的关注。该类细菌优先在肿瘤的缺氧区定植,通过重塑肿瘤免疫微环境、激活抗肿瘤免疫等多种机制杀伤肿瘤细胞。在此基础上,通过遗传工程技术构建重组抗肿瘤菌株,靶向肿瘤并在肿瘤核心区分泌治疗性蛋白或核酸药物,或与其他抗癌疗法联用,有望成为种新的癌症治疗策略。本文围绕已开展临床实验的抗肿瘤细菌,介绍不同抗肿瘤细菌的研究进展及其临床应用现状,为肿瘤的细菌免疫治疗提供新思路。Due to the complexity of tumor microenvironment,traditional cancer therapies have serious limitations,such as poor drug responsiveness,toxic side effects,difficulty in reaching deeper tumors,and tumors prone to recurrence.In recent years,bacterial⁃mediated cancer immunotherapy is attracting attention with its unique advantages.These bacteria preferentially colonize the hypoxic zone of tumors and kill tumor cells through various mechanisms,such as reshaping the tumor immune microenvironment and activating anti⁃tumor immunity.Based on this,genetic engineering techniques to construct recombinant antitumor strains that target tumors and secrete therapeutic proteins or nucleic acid drugs in the tumor core or in combination with other anticancer therapies are promising as a new cancer treatment strategy.This paper introduces the research progress of different antitumor bacteria and their clinical application status,and provides new ideas for bacterial immunotherapy of tumors.

关 键 词：溶瘤菌 卡介苗 李斯特菌 沙门氏菌 诺氏梭菌 益生菌 

分 类 号：R730.5[医药卫生—肿瘤]