A Nested Case-Control Study to Explore the Association between Immunoglobulin G N-glycans and Ischemic Stroke  

作　　者：WANG Bi Yan SONG Man Shu ZHANG Jie MENG Xiao Ni XING Wei Jia WANG You Xin 

机构地区：[1]Beijing Key Laboratory of Clinical Epidemiology,School of Public Health,Capital Medical University,Beijing 100069,China [2]Department of Health Management,the Second Affiliated Hospital,the Fourth Military Medical University,Xi'an 710003,Shaanxi,China [3]School of Medical and Health Sciences,Edith Cowan University,Perth WA 6027,Australia [4]School of Public Health,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250117,Shandong,China [5]Centre for Precision Medicine,Edith Cowan University,Perth WA 6027,Australia

出　　处：《Biomedical and Environmental Sciences》2023年第5期389-396,共8页生物医学与环境科学（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China [No.81673247, 81872682;81903401]。

摘　　要：Objective This study prospectively investigates the association between immunoglobulin G(IgG)N-glycan traits and ischemic stroke(IS) risk.Methods A nested case-control study was conducted in the China suboptimal health cohort study,which recruited 4,313 individuals in 2013–2014. Cases were identified as patients diagnosed with IS, and controls were 1:1 matched by age and sex with cases. Ig G N-glycans in baseline plasma samples were analyzed.Results A total of 99 IS cases and 99 controls were included, and 24 directly measured glycan peaks(GPs) were separated from Ig G N-glycans. In directly measured GPs, GP4, GP9, GP21, GP22, GP23, and GP24 were associated with the risk of IS in men after adjusting for age, waist and hip circumference,obesity, diabetes, hypertension, and dyslipidemia. Derived glycan traits representing decreased galactosylation and sialylation were associated with IS in men(FBG2S2/(FBG2 + FBG2S1 + FBG2S2): odds ratio(OR) = 0.92, 95% confidence interval(CI): 0.87–0.97;G1n: OR = 0.74, 95% CI: 0.63–0.87;G0n: OR =1.12, 95% CI: 1.03–1.22). However, these associations were not found among women.Conclusion This study validated that altered Ig G N-glycan traits were associated with incident IS in men, suggesting that sex discrepancies might exist in these associations.

关 键 词：Ischemic stroke Immunoglobulin G N-GLYCANS Nested case-control study 

分 类 号：R743.3[医药卫生—神经病学与精神病学]