Promotion of liquid-to-solid phase transition of cGAS by Baicalein suppresses lung tumorigenesis  

作　　者：Tiansheng Zheng Haipeng Liu Yifan Hong Yajuan Cao Qing Xia Chengge Qin Ming Li Russel J.Reiter Yidong Bai Lihong Fan 

机构地区：[1]Department of Respiratory Medicine,Shanghai Tenth People’s Hospital,Tongji University School of Medicine,Shanghai 200072,China [2]Department of Integrated Traditional Chinese&Western Medicine,Shanghai Tenth People’s Hospital,Tongji University School of Medicine,Shanghai 200072,China [3]Clinical Translational Research Center,Shanghai Pulmonary Hospital,Tongji University School of Medicine,Shanghai 200433,China [4]Institute of Energy Metabolism and Health,Shanghai Tenth People’s Hospital,Tongji University School of Medicine,Shanghai 200072,China [5]Institute of Molecular Physiology,Institue of Cancer Research,Shenzhen Bay Laboratory,Shenzhen 518132,China [6]Medical School of Nantong University,Nantong,Jiangsu 22601,China [7]Department of Cell Systems and Anatomy,University of Texas Health San Antonio,San Antonio,Texas 78229,USA

出　　处：《Signal Transduction and Targeted Therapy》2023年第4期1392-1395,共4页信号转导与靶向治疗（英文）

基　　金：the National Natural Science Foundation of China(Nos.31770131,81473469 to L.F.and 81922030 to H.L.);International Cooperation Project of the Belt and Road(No.20400750600);Construction project of Shanghai TCM-intigrated innovative flagship hospital(ZY(2021-2023)-0205-05,ZXXT-202203);Shanghai Municipal Commission of Health and Family Plan(201840056);H.L.was sponsored by Shanghai Shuguang Program(20SG19).

摘　　要：Dear Editor,Kras and p53 mutation are among the most common gene mutations in lung cancer,which has both the highest incidence and mortality rate among cancers.1 Kras/p53 mutation also causes mitochondrial dysfunction,which has been implicated to promote the inflammation-to-cancer transition.2 We established a lung adenocarcinoma model by using conditional alleles of KrasLSLG12D/p53flox/flox in mice3 to evaluate the effect of Baicalein(5,6,7-trihydroxyflavone),a principal component of Scutellaria baicalensis in traditional Chinese medicine,4 on the initiation and progression of lung cancer.Cre-mediated expression of KrasG12D and deletion of p53 caused obvious tumor lesions in the lung,which were strongly inhibited by the administration of Baicalein(Fig.1a,b and Supplementary Fig.1a,b),indicating that Baicalein is highly potent in inhibiting the progression of primary lung cancer.

关 键 词：LUNG BAICALEIN inhibited 

分 类 号：R734.2[医药卫生—肿瘤]