RNA甲基化转移酶METTL3在白血病中的研究进展  

Advances in the study of RNA methylated transferase METTL3 in leukemia

作　　者：杜佳慧 王晓晓(综述) 刘松柏(审校) DU Jiahui;WANG Xiaoxiao;LIU Songbai(Suzhou Key Laboratory of Medical Biotechnology,Suzhou Vocational Health College,Suzhou,Jiangsu 215009,China)

机构地区：[1]苏州卫生职业技术学院苏州检验医学生物技术重点实验室,江苏苏州215009

出　　处：《重庆医学》2023年第11期1732-1737,共6页Chongqing medicine

基　　金：国家自然科学基金面上项目(81970138);江苏省苏州市科技局民生科技医疗卫生科技创新关键技术攻关项目(SKY2021029);江苏高校“青蓝工程”中青年学术带头人项目(2021);苏州卫生职业技术学院青年科技专项(szwzy202011);苏州卫生职业技术学院科技创新团队项目(SZWZYTD201804);2021年度江苏省高校优秀科技创新团队项目。

摘　　要：近年来,RNA修饰成为表观遗传调控的研究新领域,其中,N6-甲基腺苷(m6A)修饰是发生在腺嘌呤第六位N原子上的甲基化修饰,是真核细胞mRNA最常见、最丰富的化学修饰,由甲基转移酶复合体、去甲基化转移酶及相应的阅读器协同调控,对维持mRNA的稳定性、调节剪接和翻译等过程具有重要意义,并参与肿瘤、生殖、生物节律等多种病理、生理过程。甲基转移酶样蛋白3(METTL3)作为核心成分,在正常造血和恶性血液肿瘤中起着至关重要的作用。该文重点关注METTL3的结构,及其在正常造血和血液恶性肿瘤中的作用,以及METTL3治疗血液肿瘤的潜力,归纳METTL3在白血病中的研究进展及相关作用机制,为白血病的治疗提供新的思路。RNA modification has become a new field of epigenetic regulation in recent years.N6-methyladenosine(m6A)modification,which occurs on the sixth Natom of adenine,is the most common and abundant chemical modification of mRNA in eukaryotic cells.It is regulated by methyltransferase complexes,demethylated transferase and their corresponding readers.It is of great significance to maintain the stability of mRNA,regulat splicing and translation,and participate in a various of pathological and physiological processes such as tumor,reproduction and biological rhythm.Methyltransferase-like protein 3(METTL3),as a core component,plays a crucial role in normal and hematogenic neoplasia.This article focuses on the structure of METTL3,the role of METTL3 in normal hematopoietic and hematologic malignancies,and the potential of METTL3 in the treatment of hematologic tumors.The research progress and related mechanism of METTL3 in leukemiaare summarized to provide new ideas for the treatment of leukemia.

关 键 词：N6甲基腺苷 甲基转移酶样蛋白3 白血病 小分子抑制剂 研究进展 

分 类 号：R733.71[医药卫生—肿瘤]