多环芳烃暴露对神经行为功能影响的研究进展  

Research progress on the effects of polycyclic aromatic hydrocarbonsexposure on neurobehavioral function

作　　者：甄华龙 江敏敏 陶芳标[1,2,3] ZHEN Hua-long;JIANG Min-min;TAO Fang-biao(School of Public Health,Anhui Medical University,Hefei,Anhui 230032,China;不详)

机构地区：[1]安徽医科大学公共卫生学院,安徽合肥230032 [2]出生人口健康教育部重点实验室 [3]人口健康与优生安徽省重点实验室

出　　处：《现代预防医学》2023年第10期1889-1894,共6页Modern Preventive Medicine

基　　金：国家自然科学基金(82003419)。

摘　　要：多环芳烃(polycyclic aromatic hydrocarbons,PAHs)是一类具有神经毒性的环境污染物,流行病学研究显示PAHs对儿童和成人神经系统具有不良影响。本文总结近年来国内外有关PAHs暴露的神经毒性的人群流行病学和实验室研究证据;并从目前研究较为清楚的氧化应激、DNA损伤以及胆碱能系统机制介绍PAHs暴露对人类神经行为功能影响的生物学机制,为确定环境相关危险因素、预防其不良作用及后续开展相关研究提供参考依据。Polycyclic aromatic hydrocarbons(PAHs),as one kind of environmental pollutants,have neurotoxicity.Epidemiological studies have preliminarily shown that PAHs have adverse effects on the nervous system of children and adults.This article reviewed evidence from laboratory and epidemiological studies on the neurotoxicity of PAHs exposure in recent years,and introduced three possible biological mechanisms including oxidative stress,DNA damage and cholinergic system,so as to provide a reference for determining environmental risk factors,preventing the adverse effects and guiding further researches.

关 键 词：多环芳烃 成人神经行为 儿童智力 儿童行为 

分 类 号：R114[医药卫生—卫生毒理学]