Peripheral and central control of obesity by primary cilia  

作　　者：Yue Wu Jun Zhou Yunfan Yang 

机构地区：[1]Center for Cell Structure and Function,Shandong Provincial Key Laboratory of Animal Resistance Biology,Collaborative Innovation Center of Cell Biology in Universities of Shandong,College of Life Sciences,Shandong Normal University,Jinan,Shandong 250014,China [2]State Key Laboratory of Medicinal Chemical Biology,Haihe Laboratory of Cell Ecosystem,College of Life Sciences,Nankai University,Tianjin 300071,China [3]Department of Cell Biology,School of Basic Medical Sciences,Cheeloo College of Medicine,Shandong University,Jinan,Shandong 250012,China

出　　处：《Journal of Genetics and Genomics》2023年第5期295-304,共10页遗传学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(32100948,32100614,31991193);Natural Science Foundation of Shandong Province(ZR2021QC069).

摘　　要：Primary cilia are hair-like structures that protrude from the cell surface.They are capable of sensing external cues and conveying a vast array of signals into cells to regulate a variety of physiological activities.Mutations in cilium-associated genes are linked to a group of diseases with overlapping clinical manifestations,collectively known as ciliopathies.A significant proportion of human ciliopathy cases are accompanied by metabolic disorders such as obesity and type 2 diabetes.Nevertheless,the mechanisms through which dysfunction of primary cilia contributes to obesity are complex.In this review,we present an overview of primary cilia and highlight obesity-related ciliopathies.We also discuss the potential role of primary cilia in peripheral organs,with a focus on adipose tissues.In addition,we emphasize the significance of primary cilia in the central regulation of obesity,especially the involvement of ciliary signaling in the hypothalamic control of feeding behavior.This review therefore proposes a framework of both peripheral and central regulation of obesity by primary cilia,which may benefit further exploration of the ciliary role in metabolic regulation.

关 键 词：CILIOPATHY METABOLISM Adipose tissue ADIPOGENESIS HYPOTHALAMUS 

分 类 号：R589.2[医药卫生—内分泌]