黄酮类化合物减轻阿尔茨海默病Aβ沉积及Tau过度磷酸化的作用  

Effects of flavonoids on reducing Aβ deposition and Tau hyperphosphorylation in Alzheimer's disease

作　　者：刘蓓 李冀宏[1] 王冕 彭亚会[1] 郑天虎[1] LIU Bei;LI Jihong;WANG Mian;PENG Yahui;ZHENG Tianhu(Department of Biochemistry and Molecular Biology,Harbin Medical University,Harbin 150086,China)

机构地区：[1]哈尔滨医科大学生物化学与分子生物学教研室,哈尔滨150086

出　　处：《生命的化学》2023年第4期570-578,共9页Chemistry of Life

基　　金：大兴安岭科技局科技研发项目(2021-9);黑龙江省教育科学“十四五”规划2022年重点课题(GJB1422755)。

摘　　要：阿尔茨海默病(Alzheimer's disease,AD)是全世界患病人数最多的神经退行性疾病,从神经病理角度来看它具有以β淀粉样蛋白(amyloid β-protein,Aβ)聚集物为主形成的老年斑和Tau蛋白过度磷酸化形成的神经纤维缠结(neurofibrillary tangles,NFTs)两大特征。黄酮类化合物是广泛存在于水果、蔬菜中的一类多酚类化合物,主要有六大类。多种黄酮类化合物经研究证实具有减轻Aβ沉积以及抑制Tau蛋白过度磷酸化方面的活性。本综述主要描述了AD的两个主要病理特征和黄酮类化合物对其作用的机制。Alzheimer's disease(AD)is the most prevalent neurodegenerative disorder.From a neuropathological point of view,AD is characterized by the deposited senile plaques mainly formed by aggregates of amyloidβ-protein(Aβ)and neurofibrillary tangles(NFTs)formed by Tau protein hyperpho-sphorylation.Flavonoids are polyphenolic compounds spotted in various fruits and vegetables,mainly in six categories.Many studies have confirmed that a variety of flavonoids can reduce Aβdeposition and/or inhibit Tau protein hyperphosphorylation.This review mainly describes these two main pathological features of AD and the mechanism by which flavonoids act on them.

关 键 词：阿尔茨海默病 黄酮类化合物 淀粉样斑块 神经纤维缠结 

分 类 号：R749.16[医药卫生—神经病学与精神病学]