More than just a histone deacetylase:cytoplasmic SIRT6 facilitates fatty acid oxidation through ACSL5 deacetylation  

作　　者：Shuoshuo Li Zengqiang Yuan 

机构地区：[1]The Brain Science Center,Beijing Institute of Basic Medical Sciences,Beijing 100850,China

出　　处：《Acta Biochimica et Biophysica Sinica》2023年第3期525-527,共3页生物化学与生物物理学报（英文版）

基　　金：supported by the grants from the National Natural Science Foundation of China(Nos.82230042 and 81930029 to Z.Y.).

摘　　要：Nonalcoholic fatty liver disease(NAFLD)is the most common liver disease worldwide;it affects up to 25%–30%of the global population.NAFLD encompasses a spectrum of conditions,ranging from hepatic steatosis and nonalcoholic steatohepatitis(NASH)to fibrosis and cirrhosis.Further progression of NAFLD can lead to hepatocellular carcinoma[1].Despite being researched for decades,effective therapeutic drugs for NAFLD remain lacking.

关 键 词：NAFLD DRUGS liver 

分 类 号：R575.5[医药卫生—消化系统]