Different serum levels of IgG and complements and recurrence rates in IgG4-positive and negative lacrimal gland benign lymphoepithelial lesion  

作　　者：Rui Liu Nan Wang Jin-Jin Wang Jing Li Xin Ge Jing-Xue Zhang Jian-Min Ma 

机构地区：[1]Beijing Ophthalmology and Visual Sciences Key Laboratory,Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China

出　　处：《International Journal of Ophthalmology(English edition)》2023年第6期876-883,共8页国际眼科杂志（英文版）

基　　金：Supported by Beijing Hospitals Authority’ Ascent Plan (No.DFL20190201);Natural Science Foundation of Beijing (No.7222025);Beijing Science and Technology Rising Star Program-Cross-cooperation (No.20220484218)。

摘　　要：·AIM:To analyze the differences in immune indicators and prognosis between Ig G4-positive and negative lacrimal gland benign lymphoepithelial lesion(LGBLEL).·METHODS:This was a single-center retrospective clinical study including 105 cases of Ig G4-positive LGBLEL and 41 cases of Ig G4-negative LGBLEL.Basic information,related indicators of peripheral venous blood samples using immunoscattering turbidimetry,treatment(partial surgical excision and glucocorticoid therapy)and prognosis(recurrence and death)were collected.Survival curves for recurrence were created using the Kaplan-Meier analysis.Univariate analysis and multivariate regression analysis were used to analyze prognostic factors.·RESULTS:The mean age was 50.10±14.23y and 44.76±11.43y(P=0.033)in Ig G4-positive and negative group respectively.The serum C3 and C4 was lower in Ig G4-positive group(P=0.005,P=0.002),while the serum Ig G and Ig G2 was higher in Ig G4-positive group(P=0.000 and P=0.008).Twenty-one cases had recurrence in Ig G4-positive group and 3 cases recurrence in Ig G4-negative group.The 5-year recurrence-free cumulative percentages of Ig G4-positive group was 81.85%,and 83.46%in the Ig G-negative group(P=0.216).The history of preoperative glucocorticoid therapy,serum C4,Ig G1 and Ig G2 were the factors affecting recurrence in Ig G4-positive group,while serum C4,and Ig G1 were the factors affecting recurrence of LGBLEL.·CONCLUSION:Serum C4 and Ig G1 are the factors affecting recurrence of LGBLEL,while the Ig G4 does not affect recurrence of LGBLEL.

关 键 词：benign lymphoepithelial lesion lacrimal gland IGG4 COMPLEMENT PROGNOSIS 

分 类 号：R777.21[医药卫生—眼科]