Ileocecal lavage fluid for gut microbiota investigation in children with gastrointestinal diseases  

作　　者：Hua-Hai Chen Xing Wang Ling Wang Hai-Feng Liu Ye-Shi Yin 

机构地区：[1]Key Laboratory of Comprehensive Utilization of Advantage Plants Resources in Hunan South,College of Chemistry and Bioengineering,Hunan University of Science and Engineering,Yongzhou,Hunan,P.R.China [2]State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products,Institute of Food Research,Zhejiang Academy of Agricultural Sciences,Hangzhou,Zhejiang,P.R.China [3]Children’s Hospital of Shanghai,Children’s Hospital of Shanghai Jiaotong University,Shanghai,P.R.China

出　　处：《Gastroenterology Report》2022年第1期606-608,共3页胃肠病学报道（英文）

基　　金：supported by the National Natural Science Foundation of China[No.31800119];the Hunan Natural Science Foundation[No.2020JJ2016,No.2018JJ3200,No.2019JJ40092,No.2019JJ50198];the construct program of applied characteristic discipline in Hunan University of Science and Engineering.

摘　　要：Introduction The ileocecal region is the end point of colonoscopy and comprises the junction of the ileum,cecum,and appendix.The ileocecal region has been reported as a common lesion site for various intestinal diseases(e.g.Crohn’s disease[1],intestinal tuberculosis[2],and primary colorectal lymphoma[3]).However,to date,there have been few studies on the intestinal microbiota of the ileocecal region,because the sampling is relatively difficult and with only a local biopsy it is difficult to represent the whole region without deviation.Compared with ileocecal mucosa sampling,the collection of ileocecal lavage fluid is easier to be accepted by patients and can avoid the interference of human genomic DNA in the process of bacterial genome sequencing.

关 键 词：DISEASES FLUID LAVAGE 

分 类 号：R574[医药卫生—消化系统]