棒曲霉素的毒性及其机制研究进展  

Research Progress on the Toxicity and Mechanism of Action of Patulin

作　　者：李勇 单硕 吴丹舟 胡淑恒[2] 许子牧 朱瑞瑜[1] LI Yong;SHAN Shuo;WU Danzhou;HU Shuheng;XU Zimu;ZHU Ruiyu(School of Biological and Chemical Engineering,Zhejiang University of Science and Technology,Hangzhou 310023,China;School of Resources and Environmental Engineering,Hefei University of Technology,Hefei 230009,China;Anhui Engineering Consulting Institute,Hefei 230001,China)

机构地区：[1]浙江科技学院生物与化学工程学院,浙江杭州310023 [2]合肥工业大学资源与环境工程学院,安徽合肥230009 [3]安徽省工程咨询研究院,安徽合肥230001

出　　处：《食品科学》2023年第11期309-316,共8页Food Science

基　　金：浙江省基础公益研究计划项目(LGN20C200012);国家自然科学基金青年科学基金项目(31601561);浙江省重点研发计划项目(2020C02024)。

摘　　要：棒曲霉素作为一种有毒的真菌次级代谢产物,广泛存在于果蔬、谷物、坚果等食品及中药材中,并可通过食物摄入、皮肤接触等方式进入机体,进而对人类和牲畜的健康造成严重威胁。棒曲霉素具有基因毒性、免疫毒性、生殖毒性等多种毒性,能够损伤机体的肠、肾、肝等器官组织;棒曲霉素的毒性机制包括诱导生物大分子结构损伤、诱导氧化应激损伤、诱导细胞自噬、破坏肠道菌群稳态等。本文介绍近年来棒曲霉素在食品中的污染情况,重点阐述棒曲霉素的毒性及其毒性机制的最新研究进展,旨在为棒曲霉素的解毒研究提供理论参考。Patulin,a toxic secondary metabolite of fungi,exists widely and stably in fruits,vegetables,grains,nuts and Chinese medicinal materials.Patulin enters the body through skin contact or food intake,posing a great threat to the health of humans and animals.Previous studies have shown that patulin can induce genotoxicity,immunotoxicity and reproductive toxicity,damaging the intestine,kidney,liver and other organs in the body.The toxic mechanism of patulin involves inducing damage to biological macromolecular structures,oxidative stress injury and cell autophagy as well as damaging intestinal flora homeostasis.In this article,the recent status of patulin contamination in foods is reviewed,with an emphasis on the latest progress in research on the toxicity and mechanism of action of patulin.It is hoped that this review will provide a theoretical basis for patulin detoxification.

关 键 词：棒曲霉素 污染 毒性 毒性机制 

分 类 号：TS201.6[轻工技术与工程—食品科学]