A shifting adversary:control of pancreatic cancer transcriptomic subtypes  

作　　者：Charles J.David 

机构地区：[1]Department of Basic Medicine,Tsinghua University School of Medicine,Beijing 100084,China

出　　处：《Journal of Cancer Metastasis and Treatment》2022年第1期253-264,共12页癌症转移与治疗（英文版）

摘　　要：Cellular plasticity,the dynamic ability of cells to adopt distinct transcriptional states,plays a well-known role in the pancreas during the initiation of pancreatic ductal adenocarcinoma(PDA),the most common form of pancreatic cancer.It is now becoming clear that plasticity also plays an important role after the emergence of PDA.PDA is composed of two major transcriptional subtypes,classical and basal-like,with important biological differences.Recent work has indicated that individual tumors can be comprised of cells of each subtype,and that tumor subtype can change during the evolution of a tumor.This suggests that PDA cells can transit between transcriptional states,with important implications for disease progression.This review discusses what is currently known about inter-subtype plasticity and how this process is controlled.

关 键 词：Pancreatic ductal adenocarcinoma transcriptional subtypes classical BASAL-LIKE squamous quasi-mesenchymal cellular plasticity transcription factors tumor microenvironment 

分 类 号：R735.9[医药卫生—肿瘤]