Cellular plasticity,the dynamic ability of cells to adopt distinct transcriptional states,plays a well-known role in the pancreas during the initiation of pancreatic ductal adenocarcinoma(PDA),the most common form of ...
supported by the Ministry of Science and Technology of China (2016YFC1302103 and 2015CB553906);the National Natural Science Foundation of China (81230051, 81472734,31170711, 81321003, and 30830048);the Beijing Natural Science Foundation (7120002);the 111 Project of the Ministry of Education, Peking University (BMU2018JC004, BMU20120314, and BMU20130364);a Leading Academic Discipline Project of Beijing Education Bureau to H.Z;a grant from the National Natural Science Foundation of China (81773199) to J.Z
Basal-like breast cancer with a luminal progenitor gene expression profile is an aggressive subtype of breast cancer with a poorer prognosis compared with other subtypes.However,genes that specifically promote basal-l...
The Triple Negative “Basal-like” breast cancer (TNBL) tumours have a high proliferative capacity and develop a resistance phenotype associated with metastases. However, the management of TNBL carcinomas is still not...
Supported by The National Cancer Institute(NCI)of National Institutes of Health(NIH)of the United States of America to Zhou Q,Nos.5R01CA157779-03 and 5R01CA163820-04
Ductal carcinoma in situ (DCIS) is a category of early stage, non-invasive breast tumor defined by the intraductal proliferation of malignant breast epithelial cells. DCIS is a heterogeneous disease composed of mult...
Adenoid cystic carcinoma(ACC) of the breast is a rare special subtype of breast cancer characterized by the presence of a dual cell population of luminal and basaloid cells arranged in specific growth patterns. Most b...
High levels of tubulin expression have been described in a variety of human malignant tumors, and glu-tubulin, in which the C-terminal tyrosine of α-tubulin is removed by tubulin carboxypeptidase. Over-expression has...