Adenoid cystic carcinoma of breast: Recent advances  

作　　者：Kosuke Miyai Mary R Schwartz Mukul K Divatia Rose C Anton Yong Wook Park Alberto G Ayala Jae Y Ro 

机构地区：[1]Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College of Cornell University,Houston, TX 77030, United States [2]Department of Basic Pathology, National Defense Medical College, Saitama 359-0042, Japan [3]Department of Pathology, Hanyang University, Guri Hospital, 153 Gyeongchun-ro, Guri, Gyeonggi-do 471-701, South Korea

出　　处：《World Journal of Clinical Cases》2014年第12期732-741,共10页世界临床病例杂志

摘　　要：Adenoid cystic carcinoma(ACC) of the breast is a rare special subtype of breast cancer characterized by the presence of a dual cell population of luminal and basaloid cells arranged in specific growth patterns. Most breast cancers with triple-negative, basal-like breast features(i.e., tumors that are devoid of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression, and express basal cell markers) are generally high-grade tumors with an aggressive clinical course. Conversely, while ACCs also display a triple-negative, basal-like phenotype, they are usually low-grade and exhibit an indolent clinical behavior. Many discoveries regarding the molecular and genetic features of the ACC, including a specific chromosomal translocation t(6;9) that results in a MYB-NFIB fusion gene, have been made in recent years. This comprehensive review provides our experience with ACC of the breast, as well as an overview of clinical, histopathological, and molecular genetic features.Adenoid cystic carcinoma(ACC) of the breast is a rare special subtype of breast cancer characterized by the presence of a dual cell population of luminal and basaloid cells arranged in specific growth patterns. Most breast cancers with triple-negative, basal-like breast features(i.e., tumors that are devoid of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression, and express basal cell markers) are generally high-grade tumors with an aggressive clinical course. Conversely, while ACCs also display a triple-negative, basal-like phenotype, they are usually low-grade and exhibit an indolent clinical behavior. Many discoveries regarding the molecular and genetic features of the ACC, including a specific chromosomal translocation t(6;9) that results in a MYB-NFIB fusion gene, have been made in recent years. This comprehensive review provides our experience with ACC of the breast, as well as an overview of clinical, histopathological, and molecular genetic features.

关 键 词：ADENOID CYSTIC carcinoma BREAST Triplenegative and BASAL-LIKE PHENOTYPE HISTOLOGY Molecular genetic features 

分 类 号：R737.9[医药卫生—肿瘤]