The role of MT1-MMP in the progression and metastasis of osteosarcoma  

作　　者：Hannah L.M.Spencer Steven D.Shnyder Paul M.Loadman Robert A.Falconer 

机构地区：[1]Institute of Cancer Therapeutics,Faculty of Life Sciences,University of Bradford,Bradford BD71DP,UK

出　　处：《Journal of Cancer Metastasis and Treatment》2022年第1期564-578,共15页癌症转移与治疗（英文版）

基　　金：This work was supported by the Bone Cancer Research Trust (No. BCRT 6218).

摘　　要：The dysregulation of Membrane-type 1 matrix metalloproteinase(MT1-MMP)has been extensively studied in numerous cancer types,and plays key roles in angiogenesis,cancer progression,and metastasis.MT1-MMP is a predictor of poor prognosis in osteosarcoma(OS),yet the molecular mechanisms of disease progression are unclear.This review provides a summary of the literature relating to the gene and protein expression of MT1-MMP(MMP-14)in OS clinical samples,evaluates the expression in cell lines and experimental models,and analyses its potential role in the progression and metastasis of OS.In addition,the therapeutic potential of MT1-MMP as a drug target has been assessed.Due to the biological complexity of MMPs,inhibition has proven to be challenging.However,exploiting the expression and proteolytic capacity of MT1-MMP could open new avenues in the search for novel,safer and selective drugs for use in OS.

关 键 词：Matrix metalloproteinase membrane-type OSTEOSARCOMA MT1-MMP 

分 类 号：R738.1[医药卫生—肿瘤]