Scaffold proteins of cancer signaling networks: The paradigm of FK506 binding protein 51 (FKBP51) supporting tumor intrinsic properties and immune escape  

作　　者：LAURA MARRONE MASSIMO D’AGOSTINO CAROLINA GIORDANO VALERIA DI GIACOMO SIMONA URZINI CHIARA MALASOMMA MARIA PAOLA GAMMELLA MARTINA TUFANO SIMONA ROMANO MARIA FIAMMETTA ROMANO 

机构地区：[1]Department of Molecular Medicine and Medical Biotechnology,University of Naples Federico II,Naples,80131,Italy [2]Dipartimento di Diagnostica per Immagini e Neuroradiologia,Fondazione Policlinico Universitario“A.Gemelli”IRCCS,UniversitàCattolica S.Cuore,Rome,Italy

出　　处：《Oncology Research》2023年第4期423-436,共14页肿瘤学研究（英文）

基　　金：Funded by National Center for Gene Therapy and Drugs Based on RNA Technology MUR-CN3 CUP E63C22000940007.

摘　　要：Scaffold proteins are crucial regulators of signaling networks,and their abnormal expression may favor the development of tumors.Among the scaffold proteins,immunophilin covers a unique role as‘protein-philin’(Greek‘philin’=friend)that interacts with proteins to guide their proper assembly.The growing list of human syndromes associated with the immunophilin defect underscores the biological relevance of these proteins that are largely opportunistically exploited by cancer cells to support and enable the tumor’s intrinsic properties.Among the members of the immunophilin family,the FKBP5 gene was the only one identified to have a splicing variant.Cancer cells impose unique demands on the splicing machinery,thus acquiring a particular susceptibility to splicing inhibitors.This review article aims to overview the current knowledge of the FKBP5 gene functions in human cancer,illustrating how cancer cells exploit the scaffolding function of canonical FKBP51 to foster signaling networks that support their intrinsic tumor properties and the spliced FKBP51s to gain the capacity to evade the immune system.

关 键 词：IMMUNOPHILIN Alternative splicing Signal transduction 

分 类 号：R730.51[医药卫生—肿瘤]