四氧化三铁纳米粒子在酶催化领域的应用研究进展  

Research Progress on the Application of Fe_(3)O_(4) Nanoparticles in the Field of Enzyme Catalysis

作　　者：石婧怡 李兆周[1] 王耀[1] 陈秀金[1] 牛华伟 李芳[1] 高红丽[1] SHI Jing-yi;LI Zhao-zhou;WANG Yao;CHEN Xiu-jin;NIU Hua-wei;LI Fang;GAO Hong-li(Henan International Joint Laboratory of Food Green Processing and Quality Safety Control,College of Food and Bioengineering,Henan University of Science and Technology,Luoyang 471000,China)

机构地区：[1]河南科技大学食品与生物工程学院,河南省食品绿色加工与质量安全控制国际联合实验室,河南洛阳471000

出　　处：《化学试剂》2023年第7期34-42,共9页Chemical Reagents

基　　金：河南省优秀青年科学基金项目(202300410121);洛阳市公益性行业科研专项(2202021A);国家自然科学基金项目(31701694,U1504330和31702218);河南省青年人才托举工程项目(2020HYTP029);河南省研究生教育改革与质量提升工程项目(HNYJS2020JD06)。

摘　　要：Fe_(3)O_(4)纳米粒子(Fe_(3)O_(4)nanoparticles, Fe_(3)O_(4)NPs)具有高比表面积、超顺磁性、易改性和低毒等优点,在固定化酶和仿生催化等领域日益受到重视。综述了Fe_(3)O_(4)NPs在固定化酶和模拟酶领域的应用,论述了Fe_(3)O_(4)纳米酶、Fe_(3)O_(4)固定化酶以及Fe_(3)O_(4)印迹模拟酶的制备方法和优缺点,探讨了Fe_(3)O_(4)印迹模拟酶在农用化学品和抗菌药物催化降解、光诱导有机物催化降解、电化学传感信号放大及肿瘤治疗等方面的研究进展,总结了Fe_(3)O_(4)NPs在酶催化领域所面临的挑战和未来的发展方向。Fe_(3)O_(4)NPs的应用越来越广泛,相关的影响因素和作用机理日趋复杂,所涉及的基础理论和技术措施仍需进一步深入研究。With the advantages of high specific surface area,superparamagnetism,easy modification and low toxicity,Fe_(3)O_(4) nanoparticles(Fe_(3)O_(4) NPs)are paying increasing attention in the fields of enzyme immobilization and biomimetic catalysis.The applications of Fe_(3)O_(4) NPs in the fields of enzyme immobilization and mimic enzymes were reviewed.The preparation methods of Fe_(3)O_(4) nanozyme,Fe_(3)O_(4) immobilized enzyme and Fe_(3)O_(4) imprinted mimic enzyme were elucidated.Their advantages and disadvantages were compared and analyzed.Furthermore,the research progress of Fe_(3)O_(4) imprinted mimic enzyme was discussed in the fields of catalytic degradations of agricultural chemicals and antibacterial drugs,photoinduced catalytic degradation of organic substances,electrochemical sensing signal amplification and tumor treatment,etc.Additionally,the facing challenges and future directions were summarized.The application of Fe_(3)O_(4) NPs is becoming more and more widespread and the related influencing factors and mechanisms of action are becoming increasingly complicated.Therefore,the basic theories and technical measures involved in the research still need to be further investigated.

关 键 词：Fe_(3)O_(4) 纳米酶 固定化酶 模拟酶 催化 

分 类 号：O631[理学—高分子化学]