Emergence of taurine as a therapeutic agent for neurological disorders  

作　　者：Ashok Jangra Priyanka Gola Jiten Singh Pooja Gond Swarnabha Ghosh Mahesh Rachamalla Abhijit Dey Danish Iqbal Mehnaz Kamal Punya Sachdeva Saurabh Kumar Jha Shreesh Ojha Dinesh Kumar Niraj Kumar Jha Hitesh Chopra Shing Cheng Tan 

机构地区：[1]Department of Pharmaceutical Sciences,Central University of Haryana,Mahendergarh,Haryana,India [2]Department of Biology,University of Saskatchewan,Saskatoon,SK,Canada [3]Department of Life Sciences,Presidency University,Kolkata,West Bengal,India [4]Department of Health Information Management,College of Applied Medical Sciences,Buraydah Private Colleges,Buraydah,Saudi Arabia [5]Department of Pharmaceutical Chemistry,College of Pharmacy,Prince Sattam Bin Abdulaziz University,Al-Kharj,Saudi Arabia [6]GloNeuro,Vishwakarma Road,Noida,India [7]Department of Biotechnology,School of Engineering&Technology(SET),Sharda University,Greater Noida,Uttar Pradesh,India [8]Department of Pharmacology and Therapeutics,College of Medicine and Health Sciences,United Arab Emirates University,Al Ain,United Arab Emirates [9]School of Bioengineering&Biosciences,Lovely Professional University,Phagwara,India [10]Department of Biotechnology,School of Applied&Life Sciences(SALS),Uttaranchal University,Dehradun,India [11]Chitkara College of Pharmacy,Chitkara University,Punjab,India [12]UKM Medical Molecular Biology Institute,Universiti Kebangsaan Malaysia,Kuala Lumpur,Malaysia

出　　处：《Neural Regeneration Research》2024年第1期62-68,共7页中国神经再生研究（英文版）

摘　　要：Taurine is a sulfur-containing,semi-essential amino acid that occurs naturally in the body.It alternates between inflammation and oxidative stress-mediated injury in various disease models.As part of its limiting functions,taurine also modulates endoplasmic reticulum stress,Ca^(2+)homeostasis,and neuronal activity at the molecular level.Taurine effectively protects against a number of neurological disorders,including stro ke,epilepsy,cerebral ischemia,memory dysfunction,and spinal cord injury.Although various therapies are available,effective management of these disorders remains a global challenge.Approximately 30 million people are affected worldwide.The design of taurine fo rmation co uld lead to potential drugs/supplements for the health maintenance and treatment of central nervous system disorders.The general neuroprotective effects of taurine and the various possible underlying mechanisms are discussed in this review.This article is a good resource for understanding the general effects of taurine on various diseases.Given the strong evidence for the neuropharmacological efficacy of taurine in various experimental paradigms,it is concluded that this molecule should be considered and further investigated as a potential candidate for neurotherapeutics,with emphasis on mechanism and clinical studies to determine efficacy.

关 键 词：antioxidant EPILEPSY γ-amino butyric acid neurodegenerative disorders NEUROPROTECTION oxidative stress spinal cord injury TAURINE 

分 类 号：R971[医药卫生—药品]