复发缓解型多发性硬化患者小世界网络受损和度中心性分析  

Impairment of small world network and degree centrality in relapse-remitting multiple sclerosis patients

作　　者：林丹 周莉[1] 谭中建[2] 周莹 韩笑[1] 崔方圆[1] LIN Dan;ZHOU Li;TAN Zhongjian;ZHOU Ying;HAN Xiao;CUI Fangyuan(Department of Encephalopathy,Dongzhimen Hospital of Beijing University of Chinese Medicine,Beijing 100700,China;Department of Radiology,Dongzhimen Hospital of Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学东直门医院脑病科,北京100700 [2]北京中医药大学东直门医院放射科,北京100700

出　　处：《中国医药导报》2023年第17期73-77,共5页China Medical Herald

基　　金：国家自然科学基金青年基金资助项目(82004303)。

摘　　要：目的探讨复发缓解型多发性硬化(RRMS)患者小世界网络的受损和度中心性改变。方法选取2014年1月至2020年1月就诊于北京中医药大学东直门医院RRMS患者20例作为观察组,并选取15名相匹配的健康志愿者作为对照组。采集所有受试者核磁数据和神经量表数据,通过GRETNA软件构建功能脑网络,使用RESTPLUS软件提取度中心性(DC)。结果两组功能脑网络均符合小世界网络属性。观察组最短路径长度高于对照组,差异有统计学意义(P<0.05),小世界属性、归一化集群系数和全局效率低于对照组,差异有统计学意义(P<0.05);在DC分析中,经FWEc校正后,观察组在额中回、楔前叶等区域DC高于对照组,在颞叶、梭状回区域DC值低于对照组,差异有高度统计学意义(P<0.01)。结论RRMS患者小世界属性等网络参数的降低,表明脑区间信息传输和交互效率减低,为RRMS患者神经病理机制提供了客观的影像学证据。Objective To investigate the small-world network impairment and changes of degree centrality in patients with relapsing-remitting multiple sclerosis(RRMS).Methods A total of 20 patients with RRMS who were admitted to Dongzhimen Hospital of Beijing University of Chinese Medicine from January 2014 to January 2020 were enrolled as the observation group,and 15 matched healthy volunteers were selected as the control group.NMR data and neural scale data of all subjects were collected,functional brain network was constructed by GRETNA software,and degree centrality(DC)was extracted by RESTPLUS software.Results Both groups of functional brain networks were consistent with small-world network properties.Compared with the control group,the global efficiency of shortest path length in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05),the small world attribute,normalized cluster coefficient,and global efficiency were lower than those in the control group,and the differences were statistically significant(P<0.05);in DC analysis,after FWEc correction,DC values in the middle frontal gyrus,precuneus,cuneus in the observation group were higher than those in the control group,and DC values in the inferior temporal gyrus,fusiform gyrus were lower than those in the control group,and the differences were highly statistically significant(P<0.01).Conclusion Patients with RRMS show a decrease in small-world attributes and other network parameters,indicating a decrease in the efficiency of information transmission and interaction between brain regions,which provides objective imaging evidence for the neuropathological mechanism of RRMS patients.

关 键 词：复发-缓解型多发性硬化 缓解期 图论 脑网络 

分 类 号：R744.5[医药卫生—神经病学与精神病学]