软骨提取物压片糖果对膝骨关节炎症状的改善  

Improvement of the symptoms of knee osteoarthritis with cartilage extract tableted candy

作　　者：丁刘刚 周勇 李泓颖 赵谋明[1] 苏国万[1] DING Liugang;ZHOU Yong;LI Hongying;ZHAO Mouming;SU Guowan(School of Food Science and Engineering,South China University of Technology,Guangzhou 510641,China;Infinitus(China)Company Ltd.,Guangzhou 510405,China;Healthy-Star Bio-Tech R&D Ltd.,Shanghai 200335,China)

机构地区：[1]华南理工大学食品科学与工程学院,广州510641 [2]无限极(中国)有限公司,广州510405 [3]健士星生物技术研发(上海)有限公司,上海200335

出　　处：《农业工程学报》2023年第9期294-302,共9页Transactions of the Chinese Society of Agricultural Engineering

基　　金：广东省重点领域研发计划项目(2020B020226005);中央高校基本科研业务费专项(2022ZYGXZR0074)。

摘　　要：为了探讨一种以软骨提取物、姜黄、葛根粉和薏苡仁粉为主要组分制成的压片糖果的改善膝骨关节炎临床疗效。该试验采用人体试食试验,通过对比试食压片糖果(试验组)和安慰剂(对照组)两组受试人群在试验前后的视觉模拟评分(visual analogue scale,VAS)、西安大略和麦克马斯特大学骨关节炎指数(WOMAC)、临床症状积分和血清白细胞介素-6(interleukin-6,IL-6)、超敏C反应蛋白(high-sensitivity C reactive protein,hs-CRP)水平等试验结果,发现试验组的VAS评分、WOMAC评分中疼痛、关节僵硬、生理功能评分和总分均在试食结束后显著降低(P<0.01),明显低于对照组;且临床症状评分中关节疼痛、压痛、晨僵时间、肿胀评分和总评分均得到显著减低(P<0.01),并呈现出较高的有效率(61.02%),显著高于对照组(有效率15.25%)(P<0.01);此外,试食后试验组的IL-6水平显著降低(P<0.05),且试食期间未见不良反应和安全性指标异常。由此可见,该压片糖果具有明显改善膝骨关节炎的疗效,能够缓解膝关节疼痛和肿胀、改善膝关节功能和活动度,控制病情,且可能与调节炎症因子IL-6有关,是一种安全有效改善膝骨关节炎症状的健康食品。The incidence of osteoarthritis is ever increasing in recent years,even at the younger age of onset.Osteoarthritis is a kind of degenerative disease,due mainly to aging,obesity,strain,trauma,joint congenital abnormalities,and joint deformity caused by articular cartilage degradation injury,joint edge and subchondral bone reactive hyperplasia of osteojoint disease,also known as degenerative arthritis or senile arthritis.The main clinical manifestations of the disease are joint pain,tenderness,stiffness,joint swelling,limited mobility,muscle atrophy,and joint deformity.Joint discomfort often occurs in the load-bearing joints,such as knee,hip,spine,and finger joints.Among them,the knee is the most prone to discomfort,where the incidence of knee osteoarthritis is much higher than that of other joint inflammation in the body.Knee osteoarthritis is generally treated to relieve the pain for better joint mobility.Current treatments for knee osteoarthritis can be divided into three categories:nondrug,drug,and surgical treatment.Non-drug treatment includes psychological education,exercise promotion,weight loss,and joint protection.Drug treatment includes the use of non-opioid analgesics,topical analgesics,non-sterol anti-inflammatory drugs,narcotic analgesics,intra-articular injections of sterols,and hyaluronic acid.Surgical treatment includes joint debridement and joint replacement.Glucosamine and chondroitin sulfate supplements have been proven to be effective in the treatment of knee osteoarthritis for the less structural damage of articular cartilage in the different clinical trials.The present study aims to investigate the clinical efficacy of a tableted candy on knee osteoarthritis.The cartilage extract,turmeric,Pueraria lobata,and Coix seed powder were also taken as the main components.Clinic human feeding trials were performed on the visual analogue scale(VAS),Western Ontario,and McMaster University Osteoarthritis Index(WOMAC),clinical symptom score,serum interleukin-6(IL-6)and high-sensitivity C reactive protein(h

关 键 词：提取 功能特性 软骨提取物 姜黄 膝骨关节炎 人体试食试验 安全性 

分 类 号：S87[农业科学—畜牧兽医]