Therapeutic poly(amino acid)s as drug carriers for cancer therapy  

作　　者：Huihui Hu Zhen Zhang Yifen Fang Lei Chen Jun Wu 

机构地区：[1]School of Biomedical Engineering,Sun Yat-sen University,Shenzhen 518107,China [2]Department of Cardiology,The Affiliated TCM Hospital of Guangzhou Medical University,Guangzhou 510120,China [3]Bioscience and Biomedical Engineering Thrust,The Hong Kong University of Science and Technology(Guangzhou),Guangzhou 511400,China [4]Division of Life Science,Hong Kong University of Science and Technology,Hong Kong 999077,China

出　　处：《Chinese Chemical Letters》2023年第6期81-89,共9页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.51973243 and 52173150);the Shenzhen Basic Research Project(No.JCYJ20190807155801657);the International Cooperation and Exchange of the National Natural Science Foundation of China(No.51820105004)。

摘　　要：As one of the top global health problems,the effective treatment of cancer is one of the most urgent clinical challenges.Currently,the main treatments for cancer include surgery,chemotherapy,radiotherapy,and gene therapy etc.Chemotherapy is one of the most commonly used treatments,however it has limitations such as highly toxic side effects and low drug utilization rate that limit its application.Gene therapy,as an emerging cancer treatment,has limitations such as drug instability,off-target effects and low internalization efficiency.Poly(amino acid)s carriers with good biocompatibility,degradability and multifunctionality as drug carriers have received much attention,as they can reduce the toxic side effects of chemotherapy,improve drug utilization,and enhance the internalization efficiency and utilization of gene drugs.However,little attention has been paid to the nature of the carriers themselves.This paper reviews the immunomodulatory,anti-inflammatory,antioxidant,internalization-promoting and apoptosispromoting functions of poly(amino acid)s drug carriers in tumor therapy to provide a theoretical basis for different carrier-drug-adapted synergistic therapies.

关 键 词：Poly(amino acid)s IMMUNOMODULATORY ANTIOXIDANT ANTI-INFLAMMATORY Apoptosis-promoting 

分 类 号：R730.5[医药卫生—肿瘤] TQ460.1[医药卫生—临床医学]