Outcomes of allograft from donor kidney microthrombi and secondary recipient thrombotic microangiopathy: should we consider loosening the belt?  

作　　者：Yamei CHENG Luying GUO Xue REN Zhenzhen YANG Junhao LV Huiping WANG Wenhan PENG Hongfeng HUANG Jianyong WU Jianghua CHEN Rending WANG 

机构地区：[1]Kidney Disease Center,the First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,China [2]Key Laboratory of Kidney Disease Prevention and Control Technology,Zhejiang Province,Hangzhou 310003,China [3]National Key Clinical Department of Kidney Diseases,Hangzhou 310003,China [4]Institute of Nephrology,Zhejiang University,Hangzhou 310003,China [5]Zhejiang Clinical Research Center of Kidney and Urinary System Disease,Hangzhou 310003,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2023年第6期524-529,共6页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：supported by the Science and Technology Department of Zhejiang Province(No.2019C03029);the National Natural Science Foundation of China(Nos.82070766,81870510,and U21A20350);the Bethune Charitable Foundation(No.GX2019010112),China.

摘　　要：There is currently a huge worldwide demand for donor kidneys for organ transplantation.Consequently,numerous marginal donor kidneys,such as kidneys with microthrombi,are used to save patients'lives.While some studies have shown an association between the presence of microthrombi in donor kidneys and an increased risk for delayed graft function(DGF)(McCall et al.,2003;Gao et al.,2019),other studies have demonstrated that microthrombi negatively impact the rate of DGF(Batra et al.,2016;Hansen et al.,2018),but not graft survival rate(McCall et al.,2003;Batra et al.,2016;Gao et al.,2019).In contrast,Hansen et al.(2018)concluded that fibrin thrombi were not only associated with reduced graft function six months posttransplantation but also with increased graft loss within the first year of transplantation.On the other hand,Batra et al.(2016)found no significant differences in the DGF rate or one-year graft function between recipients in diffuse and focal microthrombi groups.To date,however,the overall influence of donor kidney microthrombi and the degree of influence on prognosis remain controversial,necessitating further research.

关 键 词：KIDNEY throm DONOR 

分 类 号：R733.7[医药卫生—肿瘤]