Palladium-catalyzed decarbonylative methylation of aryl carboxylic acids  

作　　者：Boya Feng Guodong Zhang Xu Feng Yu Chen 

机构地区：[1]Jiangsu Key Laboratory for the Research and Utilization of Plant Resources,The Jiangsu Provincial Platform for Conservation and Utilization of Agricultural Germplasm,Institute of Botany,Jiangsu Province and Chinese Academy of Sciences,Nanjing,210014,China [2]Jiangsu Province Engineering Research Center of Eco-cultivation and High-value Utilization of Chinese Medicinal Materials,Institute of Botany,Jiangsu Province and Chinese Academy of Sciences,Nanjing,210014,China

出　　处：《Organic Chemistry Frontiers》2022年第4期1085-1089,共5页有机化学前沿（英文）

基　　金：This research was supported financially by the National Natural Science Foundation of China(No.32070360 and 31970375);the Innovation and Promotion Project for Forestry Science and Technology of Jiangsu Province(No.LYKJ[2021]18);the Open Fund of Jiangsu Key Laboratory for the Research and Utilization of Plant Resources(No.JSPKLB202201).

摘　　要：Described herein is a palladium-catalyzed decarbonylative methylation of aryl carboxylic acids using tri-methylboroxine(TMB)as the methylating reagent.The Pd(OAc)_(2)/XantPhos system is compatible with a wide range of carboxylic acids and derivatives including aroyl chloride/fluoride.The successful methylation of bio-active molecules and examples of orthogonal cross-couplings demonstrate the practicality of this method.

关 键 词：METHOD CARBONYL CATALYZED 

分 类 号：O62[理学—有机化学]