Loss of hepatic VMP1 trapped VLDL in the bilayer of endoplasmic reticulum membrane  

作　　者：Hong-Min Ni Benjamin Ding Allen Chen 

机构地区：[1]Department of Pharmacology,Toxicology and Therapeutics,University of Kansas Medical Center,Kansas City,KS,USA

出　　处：《Liver Research》2023年第2期161-163,共3页肝脏研究（英文）

基　　金：This study was supported in part by the National Institutes of Health(NIH)funds P20GM144269,R01 DK134737&R56 DK129234(HMN).

摘　　要：Non-alcoholic fatty liver disease(NAFLD)is a highly prevalent form of liver disease associated with obesity,diabetes,and other metabolic diseases.1 NAFLD is characterized by hepatocyte lipid accumulation.Left untreated,this disease can progress to nonalcoholic steatohepatitis(NASH),typified by increased hepatocyte death,hepatocyte ballooning,inflammation,and fibrosis.2,3 The molecular basis of NAFLD/NASH development and progression is still poorly understood;thus,no effective treatments currently exist to combat this burgeoning health problem.

关 键 词：AUTOPHAGY Lipid droplet Non-alcoholic fatty liver disease(NAFLD) Non-alcoholic steatohepatitis(NASH) 

分 类 号：R575[医药卫生—消化系统]