Microvessel density in patients with gastrointestinal stromal tumors:A systematic review and meta-analysis  

作　　者：Konstantinos Perivoliotis Ioannis Baloyiannis Athina A Samara Prodromos Koutoukoglou Panagiotis Ntellas Katerina Dadouli Maria Ioannou Konstantinos Tepetes 

机构地区：[1]Department of Surgery,University Hospital of Larissa,Larissa 41110,Greece [2]Research Methodology in Biomedicine,Biostatistics and Clinical Bioinformatics,University of Thessaly,4111041110,Greece [3]Department of Pathology,University Hospital of Larissa,Larissa 41110,Greece

出　　处：《World Journal of Methodology》2023年第3期153-165,共13页世界方法学杂志

摘　　要：BACKGROUND Gastrointestinal stromal tumors(GISTs)are considered the most common mesenchymal tumors of the gastrointestinal tract.Microvessel density(MVD)constitutes a direct method of vascularity quantification and has been associated with survival rates in multiple malignancies.AIM To appraise the effect of MVD on the survival of patients with GIST.METHODS This study adhered to Systematic reviews and Meta-Analyses guidelines and the Cochrane Handbook for Systematic Reviews of Interventions.Electronic scholar databases and grey literature repositories were systematically screened.The Fixed Effects or Random Effects models were used according to the Cochran Q test.RESULTS In total,6 eligible studies were identified.The pooled hazard ratio(HR)for disease free survival(DFS)was 8.52(95%CI:1.69-42.84,P=0.009).The odds ratios of disease-free survival between high and low MVD groups at 12 and 60 mo did not reach statistical significance.Significant superiority of the low MVD group in terms of DFS was documented at 36 and 120 mo(OR:8.46,P<0.0001 and OR:22.71,P=0.0003,respectively)as well as at metastases rate(OR:0.11,P=0.0003).CONCLUSION MVD significantly correlates with the HR of DFS and overall survival rates at 36 and 120 mo.Further prospective studies of higher methodological quality are required.

关 键 词：VASCULARITY Microvessel density Gastrointestinal stromal SURVIVAL META-ANALYSIS 

分 类 号：R73[医药卫生—肿瘤]