Ultrasound deep brain stimulation decelerates telomere shortening in Alzheimer’s disease and aging mice  

作　　者：Yaya Zhang Na Pang Xiaowei Huang Wen Meng Long Meng Bingchang Zhang Zhengye Jiang Jing Zhang Zhou Yi Zhiyu Luo Zhanxiang Wang Lili Niu 

机构地区：[1]Department of Neurosurgery,Xiamen Key Laboratory of Brain Center,the First Affiliated Hospital of Xiamen University,Xiamen 361003,China [2]Paul C.Lauterbur Research Center for Biomedical Imaging,Institute of Biomedical and Health Engineering,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China [3]Dongguan University of Technology,Dongguan 523808,China [4]School of Medicine,Xiamen University,Xiamen 361000,China [5]Shanghai Green Valley Pharmaceutical Co.,Ltd,Shanghai 200120,China

出　　处：《Fundamental Research》2023年第3期469-478,共10页自然科学基础研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(T2122023,12022410,12004410);Shenzhen Basic Science Research(JCYJ20200109105622824,JCYJ20200109110006136);the Natural Science Foundation of Fujian Province(2020J02063);the Xiamen Bureau of Science and Technology(3502Z20209005).

摘　　要：Telomere length is a reliable biomarker for health and longevity prediction in both humans and animals.The common neuromodulation techniques,including deep brain stimulation(DBS)and optogenetics,have excellent spatial resolution and depth penetration but require implementation of electrodes or optical fibers.Therefore,it is important to develop methods for noninvasive modulation of telomere length.Herein,we reported on a new method for decelerating telomere shortening using noninvasive ultrasound deep brain stimulation(UDBS).Firstly,we found that UDBS could activate the telomerase-associated proteins in normal mice.Then,in the Alzheimer’s disease mice,UDBS was observed to decelerate telomere shortening of the cortex and myocardial tissue and to effectively improve spatial learning and memory abilities.Similarly,UDBS was found to significantly slow down telomere shortening of the cortex and peripheral blood,and improve motor and cognitive functions in aging mice.Finally,transcriptome analysis revealed that UDBS upregulated the neuroactive ligand-receptor interaction pathway.Overall,the present findings established the critical role of UDBS in delaying telomere shortening and indicated that ultrasound modulation of telomere length may constitute an effective therapeutic strategy for aging and aging-related diseases.

关 键 词：Noninvasive ultrasound Brain stimulation Telomere length AGING Alzheimer’s disease(AD) 

分 类 号：R749.16[医药卫生—神经病学与精神病学]