Fibromatosis-like metaplastic carcinoma of the breast:Two case reports  

作　　者：Wei-Yu Bao Jiang-Hong Zhou Yan Luo Yun Lu 

机构地区：[1]Department of Breast Surgery Ⅰ,Gansu Provincial Cancer Hospital,Lanzhou 730050,Gansu Province,China [2]Department of Nursing,Gansu Provincial Cancer Hospital,Lanzhou 730050,Gansu Province,China [3]Department of Pathology,Gansu Provincial Cancer Hospital,Lanzhou 730050,Gansu Province,China [4]Functional Department,Gansu Provincial Cancer Hospital,Lanzhou 730050,Gansu Province,China

出　　处：《World Journal of Clinical Cases》2023年第18期4384-4391,共8页世界临床病例杂志

基　　金：Supported by 2020 Gansu Province Central Government Guide Local Science and Technology Development Project;Gansu Province Natural Science Fund,No.21JR1RA373.

摘　　要：BACKGROUND Fibromatosis-like metaplastic carcinoma is classified as a rare type of metaplastic carcinoma of the breast by the 2012 WHO pathological and genetic classification criteria for breast tumors,which takes hyperplastic spindle cells as the main component and is often misdiagnosed as benign stromal proliferative lesions or benign mesenchymal tumors of the breast because of its mild morphology.Here,we collected the clinical data of 2 cases of fibromatosis-like metaplastic carcinoma of the breast and performed pathomorphological observation and immunohistochemical staining of the surgically resected specimens.According to the clinical features,imaging features,immunophenotype,diagnosis and differential diagnosis of 2 cases of fibromatosis-like metaplastic carcinoma of the breast,it was further differentiated.CASE SUMMARY Case 1:A 56-year-old postmenopausal female was admitted due to"right breast mass for over 1 year and local ulceration for over 1 mo".Physical examination showed a mass with a diameter of 4.5 cm×5.5 cm palpable at 2.5 cm from the nipple at 1 o'clock in the right breast.The skin on the surface of the mass ruptured about 3 cm,with a small amount of exudation and bleeding,less clear boundary,hard texture,fair activity,without obvious tenderness.No obvious abnormality was palpable in the left breast.No enlarged lymph nodes were palpable in the bilateral axillae and bilateral supraclavicular region.After removing the mass tissue,it was promptly sent to the pathology department for examination.Case 2:Female,52-years-old,premenopausal,admitted due to"right breast mass for more than 3 mo".Physical examination showed a 4.0 cm×4.0 cm diameter mass palpable at 2.0 cm of the nipple in the lower outer 7 o'clock direction of the right breast,with less clear boundary,hard texture,fair activity,no significant tenderness,no palpable significant abnormalities in the left breast,and no palpable enlarged lymph nodes in the bilateral axillae and bilateral supraclavicular region.The mass was resected and sent fo

关 键 词：Breast cancer Fibromatosis-like metaplastic carcinoma Metaplastic carcinoma Spindle cell lesion PATHOLOGY 

分 类 号：R737.9[医药卫生—肿瘤]