Secondary Iron Overload and the Liver:A Comprehensive Review  

作　　者：Kanokwan Pinyopornpanish Adisak Tantiworawit Apinya Leerapun Atiwat Soontornpun Satawat Thongsawat 

机构地区：[1]Division of Gastroenterology and Hepatology,Department of Internal Medicine,Faculty of Medicine,Chiang Mai University,Chiang Mai,Thailand [2]Division of Hematology,Department of Internal Medicine,Faculty of Medicine,Chiang Mai University,Chiang Mai,Thailand [3]Division of Neurology,Department of Internal Medicine,Faculty of Medicine,Chiang Mai University,Chiang Mai,Thailand

出　　处：《Journal of Clinical and Translational Hepatology》2023年第4期932-941,共10页临床与转化肝病杂志（英文版）

摘　　要：Iron overload is a condition involving excessive iron deposit in various organs,the liver being the main target organ for iron deposition and overload which are associated with significant liver morbidity and mortality.Iron overload can be categorized into primary and secondary causes.Primary iron overload,so-called hereditary hemochromatosis,is a wellrecognized disease with available standard treatment recommendations.However,secondary iron overload is a more diverse disease with many unclear areas to be explored.Secondary iron overload is more prevalent than primary iron overload and occurs as a consequence of various causes which differ significantly across geographic regions.The main causes of secondary iron overload are iron-loading anemias,and chronic liver disease.The liver-related outcomes,patient outcomes,and treatment recommendations in these patients differ depending on the cause of iron overload.This review summarizes the causes,pathophysiology,liver-related outcomes,disease outcomes,and treatments of secondary iron overload.

关 键 词：Iron overload HEMOCHROMATOSIS CIRRHOSIS Hepatocellular carcinoma THALASSEMIA 

分 类 号：R575[医药卫生—消化系统]