凝血因子■Val34Leu基因突变与阿尔茨海默病的相关性研究  

Correlation study of coagulation factor■Val34Leu gene mutation and sporadic Alzheime's disease

作　　者：欧阳晓春 田承为 黄晓峰[3] 管丽红 张莉[1] 王婕妤 廖祥萍 刘南海[5] OUYANG Xiao-chun;TIAN Cheng-wei;HUANG Xiao-feng;GUANG Li-hong;ZHANG Li;WANG Jie-yu;LIAO Xiang-ping;LIU Nan-hai(Department of Neurology,No.908 Hospital of the People's Liberation Army Joint Logistics Support Force,Nanchang,Jiangxi 330002;Ganzhou Retired Cadres Rest Home of Jiangxi Military Region;Nursing School of Gannan Medical University;The First Clinical Medical School of Gannan Medical University;The First Affiliated Hospital of Gannan Medical University,Ganzhou,Jiangxi 341000)

机构地区：[1]中国人民解放军联勤保障部队第九〇八医院神经内科,江西南昌330002 [2]江西省军区赣州离职干部休养所 [3]赣南医学院护理学院 [4]赣南医学院第一临床医学院 [5]赣南医学院第一附属医院神经内科,江西赣州341000

出　　处：《赣南医学院学报》2023年第5期485-487,496,共4页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：江西省教育厅科学技术研究项目(GJJ150960);赣南医学院产学研项目(CP201407)。

摘　　要：目的:探讨凝血因子■Val34Leu基因突变与散发性阿尔茨海默病(Sporadic Alzheimer's disease,SAD)的关系。方法:应用聚合酶链反应-单链构象多态性(Polymerase chain reaction-single-strand conformation polymorphism,PCR-SSCP)技术与随机测序的方法检测128例SAD患者和136例健康老年人的凝血因子■Val34Leu基因突变。结果:在阿尔茨海默病组发现了1例凝血因子■基因Val34Leu突变的杂合子,正常对照组不存在凝血因子■Val34Leu基因突变。结论:凝血因子■Val34Leu的突变可能与中国人群的散发性阿尔茨海默病无关。Objective:To explore the correlation between coagulation factor■(F■)Val34Leu gene mutation and sporadic Alzheimer's disease(SAD).Methods:The mutation of FVal34Leu was detected by using polymerase chain single strand conformation polymorphismanalysis(PCR-SSCP)and random sequencing for 128 patients with SAD and 136 normal controls.Results:There was 1 F■gene Val34Leu mutation heterozygotes and no mutation of F■Val34Leu was found in 136 normal controls.Conclusion:The results indicated that F■Val34Leu mutation might have no relationship with SAD.

关 键 词：阿尔茨海默病 凝血因子■ 基因 遗传学 

分 类 号：R741.02[医药卫生—神经病学与精神病学]