The Tip60/Ep400 chromatin remodeling complex impacts basic cellular functions in cranial neural crest-derived tissue during early orofacial development  

作　　者：Sebastian Gehlen-Breitbach Theresa Schmid Franziska Frob Gabriele Rodrian Matthias Weider Michael Wegner Lina Gölz 

机构地区：[1]Institut für Biochemie,Friedrich-Alexander-Universit?t Erlangen-Nürnberg,Erlangen,Germanyand [2]Zahnklinik 3-Kieferorthopodie,Universitotsklinikum Erlangen und Friedrich-Alexander-Universitot Erlangen-Nürnberg,Erlangen,Germany

出　　处：《International Journal of Oral Science》2023年第2期241-254,共14页国际口腔科学杂志（英文版）

基　　金：supported by a grant from the IZKF Erlangen(E28)。

摘　　要：The cranial neural crest plays a fundamental role in orofacial development and morphogenesis.Accordingly,mutations with impact on the cranial neural crest and its development lead to orofacial malformations such as cleft lip and palate.As a pluripotent and dynamic cell population,the cranial neural crest undergoes vast transcriptional and epigenomic alterations throughout the formation of facial structures pointing to an essential role of factors regulating chromatin state or transcription levels.

关 键 词：NEURAL FUNCTIONS alterations 

分 类 号：R782.2[医药卫生—口腔医学]