Down-regulation of DNA key protein-FEN1 inhibits OSCC growth by affecting immunosuppressive phenotypes via IFN-γ/JAK/STAT-1  

作　　者：Shimeng Wang Xiangjian Wang Jun Sun Jin Yang Deyang Wu Fanglong Wu Hongmei Zhou 

机构地区：[1]State Key Laboratory of Oral Diseases&National Center of Stomatology&National Clinical Research Center for Oral Diseases&Frontier Innovation Center for Dental Medicine Plus&Department of Oral Medicine,West China Hospital of Stomatology,Sichuan University,Chengdu,China [2]Department of Oral Medicine,The Second Affiliated Hospital of Zhejiang University School of Medicine,Zhejiang University,Hangzhou,China [3]Department of Oral Medicine,Stomatological Hospital of Chongqing Medical University,Chongqing Medical University,Chongqing,China

出　　处：《International Journal of Oral Science》2023年第2期255-265,共11页国际口腔科学杂志（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.82071124,82002884,82101028,82102854)。

摘　　要：Oral squamous cell carcinoma(OSCC)escape from the immune system is mediated through several immunosuppressive phenotypes that are critical to the initiation and progression of tumors.As a hallmark of cancer,DNA damage repair is closely related to changes in the immunophenotypes of tumor cells.Although flap endonuclease-1(FEN1),a pivotal DNA-related enzyme is involved in DNA base excision repair to maintain the stability of the cell genome.

关 键 词：JAK/STAT damage SQUAMOUS 

分 类 号：R739.8[医药卫生—肿瘤]