Beyond cardiomyocytes:Cellular diversity in the heart's response to exercise  

作　　者：Lena E.Trager Margaret Lyons Alexandra Kuznetsov Cedric Sheffield Kangsan Roh Rebecca Freeman James Rhee J.Sawalla Guseh Haobo Li Anthony Rosenzweig 

机构地区：[1]Corrigan Minehan Heart Center,Division of Cardiology,Cardiovascular Research Center,Department of Medicine,Massachusetts General Hospital,Harvard Medical School,Boston,MA 02114,USA [2]University of Minnesota Medical School,Minneapolis,MI 55455,USA [3]Department of Anesthesiology and Critical Care,Massachusetts General Hospital,Harvard Medical School,Boston,MA 02115,USA [4]Institute for Heart and Brain Health,University of Michigan Medical Center,Ann Arbor,MI 48109,USA

出　　处：《Journal of Sport and Health Science》2023年第4期423-437,F0003,共16页运动与健康科学（英文）

基　　金：Supported by the NIH(R01AG061034(AR),R35HL15531(AR),R21AG077040(HL),and K08HL140200(JR));the American Heart Association(20CDA35310184(HL)and 19AMFDP34990046(JSG));Sarnoff Cardiovascular Research Foundation Fellowship award(LET and CS);Massachusetts General Hospital Sanchez-Ferguson Faculty Scholar Program(JSG)。

摘　　要：Cardiomyocytes comprise~70%to 85%of the total volume of the adult mammalian heart but only about 25%to 35%of its total number of cells.Advances in single cell and single nuclei RNA sequencing have greatly facilitated investigation into and increased appreciation of the potential functions of non-cardiomyocytes in the heart.While much of this work has focused on the relationship between non-cardiomyocytes,disease,and the heart's response to pathological stress,it will also be important to understand the roles that these cells play in the healthy heart,cardiac homeostasis,and the response to physiological stress such as exercise.The present review summarizes recent research highlighting dynamic changes in non-cardiomyocytes in response to the physiological stress of exercise.Of particular interest are changes in fibrotic pathways,the cardiac vasculature,and immune or inflammatory cells.In many instances,limited data are available about how specific lineages change in response to exercise or whether the changes observed are functionally important,underscoring the need for further research.

关 键 词：ANGIOGENESIS Cardiac fibrosis CARDIOPROTECTION HYPERTROPHY Non-cardiomyocytes Proliferation 

分 类 号：G804.2[文化科学—运动人体科学]