整合素αvβ6在头颈部鳞状细胞癌中的作用研究  

The role of integrin αvβ6 in head and neck squamous cell carcinoma

作　　者：赵瑞 华清泉[1] ZHAO Rui;HUA Qingquan(Department of Otolaryngology head and Neck Surgery,People's Hospital of Wuhan University,Wuhan 430072,China)

机构地区：[1]武汉大学人民医院耳鼻咽喉头颈外科,武汉430072

出　　处：《中国中西医结合耳鼻咽喉科杂志》2023年第3期189-194,209,共7页Chinese Journal of Otorhinolaryngology in Integrative Medicine

摘　　要：头颈部鳞状细胞癌(head and neck squamous cell carcinoma, HNSCC)起源于口腔、鼻腔、鼻窦和咽的黏膜上皮,为头颈部常见恶性肿瘤。许多患者以局部晚期病变为特征,经过手术联合放化疗后生存率仍然较低。局部复发、颈淋巴结转移、远处转移是影响HNSCC患者预后的重要因素。识别与复发和转移相关的肿瘤标志物,对预测肿瘤生物学行为和治疗策略的方向具有重要意义。大量研究证实整合素αvβ6在HNSCC中表达显著上调,而且能通过多种机制介导HNSCC肿瘤细胞的侵袭与转移。其表达的增加与HNSCC的疾病进展和较差的预后有关。因此,整合素αvβ6有望成为HNSCC预后的预测指标和治疗靶点。The Head and neck squamous cell carcinoma(HNSCC)originates from mucosal epithelium of the oral cavity,nasal cavity,sinus and pharynx,and is a common malignant tumor of the head and neck.Many patients are characterized by locally advanced disease and survival remains low after surgery combined with radiotherapy and chemotherapy.Local recurrence,cervical lymph node metastasis and distant metastasis are important factors affecting the prognosis of HNSCC patients.Identification of tumor markers associated with recurrence and metastasis is of great significance in predicting tumor biological behavior and the direction of treatment strategies.A large number of studies have confirmed that integrinαvβ6 is significantly up-regulated in head and neck squamous cell carcinoma and can mediate the invasion and metastasis of HNSCC tumor cells through various mechanisms.Increased expression is associated with disease progression and poor prognosis of HNSCC.Therefore,integrinαvβ6 is expected to be a prognostic indicator and therapeutic target for HNSCC.

关 键 词：整合素ΑVΒ6 HNSCC 侵袭转移 治疗靶点 

分 类 号：R739.91[医药卫生—肿瘤]