HNSCC

作品数:65被引量:83H指数:5
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相关领域:医药卫生更多>>
相关作者:吴煜农宋晓萌丁旭武和明叶金海更多>>
相关机构:南京医科大学武汉大学南京医科大学附属口腔医院中国医科大学更多>>
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相关基金:国家自然科学基金中国博士后科学基金重庆市自然科学基金江苏高校优势学科建设工程资助项目更多>>
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铁死亡相关基因在头颈癌中的表达及临床意义
《内蒙古师范大学学报(自然科学版)》2025年第2期111-119,共9页尚多 武旭 周兴安 苏尼特 德乐黑巴特尔 申铁兵 
内蒙古自治区自然科学基金资助项目“LncRNA GSEC竞争性结合miR-144调控CXCL8在口腔鳞癌中的作用及机制研究”(2024QN08053);内蒙古自治区高等学校科学研究资助项目“数字化导板辅助精确治疗颧眶骨折的临床研究”(NJZY21634);内蒙古医科大学联合资助项目“血清外泌体circRNA在口腔鳞癌中的差异性表达及其功能的研究”(YKD2023LH032)。
采用生物信息学方法探索与头颈鳞状细胞癌(headandnecksquamouscellcarcinoma,HNSCC)组织中铁死亡相关的基因,并探讨其与免疫细胞浸润及患者预后的相关性,为HNSCC患者提供新的分子靶点。通过GEO数据库检索筛选得到基因微阵列数据集GSE22...
关键词:HNSCC 生物信息学 免疫浸润 铁死亡 公共数据库 
Insights on Bmi-1 therapeutic targeting in head and neck cancers
《Oncology Research》2025年第2期301-307,共7页JESSIE REYES-CARMONA 
The B lymphoma Mo-MLV insertion region 1 homolog(Bmi-1)protein of the polycomb complex is an essential mediator of the epigenetic transcriptional silencing by the chromatin structure.It has been reported to be crucial...
关键词:Cancer stem cell(CSC) B lymphoma Mo-MLV insertion region 1 homolog Bmi-1 Therapeutic resistance Head and neck squamous cell carcinoma(HNSCC) Targeted therapy 
The therapeutic efficacy of different configuration nano-polydopamine drug carrier systems with photothermal synergy against head and neck squamous cell carcinoma
《Regenerative Biomaterials》2025年第1期94-112,共19页Yuhao Guo Bo Li Huixu Xie Chenzhou Wu Guixue Wang Kexin Yao Longjiang Li 
supported by research funding from the National Natural Science Foundation of China(82141130,82372735);the Sichuan Province Science and Technology Support Program(2019YJ0724,2023NSFSC1519);the China Postdoctoral Science Foundation(2022M712240);West China School/Hospital of Stomatology,Sichuan University(RCDWJS2022-10).
Head and neck squamous cell carcinoma(HNSCC)is the sixth most common malignant tumor worldwide.Considering its special anatomical site and the progressive resistance to chemotherapy drugs,the development of more effec...
关键词:nano-polydopamine(nPDA) photothermal effect thermo-chemotherapy head and neck squamous cell carcinoma(HNSCC) drug carrier system 
CXCL16 promotes proliferation of head and neck squamous cell carcinoma by regulating GPX1-mediated antioxidant levels
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第1期92-106,共15页Ru HE Hongyi JIANG Chengchi ZHANG Yuan CHEN Wenshun LIU Xinyue DENG Xiaozheng ZHU Yunye LIU Chuanming ZHENG Yining ZHANG Chengying SHAO Yanting DUAN Jiajie XU 
supported by the Scientific Research Fund of the National Health Commission-Zhejiang Provincial Health Major Science and Technology Plan Project(No.WKJ-ZJ-2415);the Key Research and Development Program of Zhejiang Province(No.2024C03166);the Traditional Chinese Medicine Science and Technology Project of Zhejiang Province(No.2022ZB020);the Zhejiang Provincial Natural Science Foundation of China(No.LY21H160049).
Numerous studies have demonstrated that the high expression of CXC motif chemokine ligand 16(CXCL16)in cancer correlates with poor prognosis,as well as tumor cell proliferation,migration,and invasion.While CXCL16 can ...
关键词:Antioxidant pathway CXC motif chemokine ligand 16(CXCL16) Glutathione peroxidase 1(GPX1) Head and neck squamous cell carcinoma(HNSCC) 
Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC
《International Journal of Oral Science》2024年第4期711-727,共17页Lixuan Wang Rongchun Yang Yue Kong Jing Zhou Yingyao Chen Rui Li Chuwen Chen Xinran Tang Xiaobing Chen Juan Xia Xijuan Chen Bin Cheng Xianyue Ren 
supported by grants from the GuangDong Basic and Applied Basic Research Foundation(No.2023A1515030121,No.2021A1515111020,No.2023A1515010246);the National Natural Science Foundation of China(No.82273148,No.82103555,No.82301086);the Science and Technology Projects in Guangzhou(No.202206080009)。
Metabolic heterogeneity plays a central role in sustaining uncontrolled cancer cell proliferation and shaping the tumor microenvironment(TME),which significantly compromises the clinical outcomes and responses to ther...
关键词:metabolism therapeutic precise 
CES1 is associated with cisplatin resistance and poor prognosis of head and neck squamous cell carcinoma
《Oncology Research》2024年第12期1935-1948,共14页CHUAN JIANG CHUNLEI LIU XI YAO JINGYA SU WEI LU ZHENGBO WEI YING XIE 
supported by the National Natural Science Foundation of China(No.82160386);the Guangxi Natural Science Foundation of China(No.2024GXNSFDA010032,2023GXNSFAA026189).
Background:Head and neck squamous cell carcinoma(HNSCC)is a prevalent form of cancer globally,with chemoresistance posing a major challenge in treatment outcomes.The efficacy of the commonly used chemotherapeutic agent...
关键词:Carboxylesterase 1(CES1) Head and neck squamous cell carcinoma(HNSCC) CHEMORESISTANCE CISPLATIN SMOKING PROGNOSIS 
Author correction to “Identification of anthelmintic parbendazole as a therapeutic molecule for HNSCC through connectivity map-based drug repositioning” [Acta Pharm Sin B 12 (2022) 2429-2442]
《Acta Pharmaceutica Sinica B》2024年第11期5089-5090,共2页Dong Liang Chen Yu Zhao Ma Xingye Yang Zhenzhen Li Xuhui Dong Xiaojun Qin Lupei Du Minyong Li 
The authors regret that a mistake occurred during the presentation of Fig.5A,in which the result of 0.1μmol/L CA-4 group appeared incorrectly when merging different imaging pictures into one.This correction does not ...
关键词:CORRECTION finding CONNECTIVITY 
Single cell analysis unveils B cell-dominated immune subtypes in HNSCC for enhanced prognostic and therapeutic stratification
《International Journal of Oral Science》2024年第3期448-459,共12页Kang Li Caihua Zhang Ruoxing Zhou Maosheng Cheng Rongsong Ling Gan Xiong Jieyi Ma Yan Zhu Shuang Chen Jie Chen Demeng Chen Liang Peng 
supported by grants from the National Natural Science Foundation of China(82173362);China Postdoctoral Science Foundation(2022M720175,2023M734003);National Science Foundation of China(82304069).
Head and neck squamous cell carcinoma(HNSCC)is characterized by high recurrence or distant metastases rate and the prognosis is challenging.There is mounting evidence that tumor-infiltrating B cells(TIL-Bs)have a cruc...
关键词:prognosis elevated offering 
Inhibitory effect of saffron on head and neck squamous cell carcinoma via targeting of ESR1 and CCND1 by its active compound crocetin被引量:1
《Traditional Medicine Research》2024年第7期25-34,共10页Xiao-Jie Wang Ming-Jun Zhang Li-Mei Cui Zhe-Ying Song Ya-Qi Wang Yu-Teng Yang Xiang-Kun Zhao Ya-Kui Mou Yu-Mei Li Xi-Cheng Song 
the Taishan Scholar Project(No.ts20190991);the Key R&D Project of Shandong Province(2022CXPT023)。
Background:Traditional Chinese medicine is promising for managing challenging and complex disorders,including cancer,and in particular,saffron is applied in treating various cancer types.However,its potential therapeu...
关键词:SAFFRON hub genes CROCETIN network pharmacology analysis HNSCC ESR1 CCND1 
Research progress on the role and mechanism of circular RNA in drug resistance of head and neck squamous cell carcinoma
《Cancer Drug Resistance》2024年第1期482-494,共13页Hongli Zeng Junshang Ge Yi Meng Qian Wang Mei Yang Zhaoyang Zeng Wei Xiong Xuyu Zu 
supported by the National Natural Science Foundation of China(U21A20382).
Drug resistance in tumors constitutes a significant obstacle to tumor therapy.Head and neck squamous cell carcinoma(HNSCC)presents a major challenge due to its deep anatomical location,limited space,and complex struct...
关键词:Head and neck squamous cell carcinoma(HNSCC) circular RNAs(circRNAs) drug resistance 
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