The B lymphoma Mo-MLV insertion region 1 homolog(Bmi-1)protein of the polycomb complex is an essential mediator of the epigenetic transcriptional silencing by the chromatin structure.It has been reported to be crucial...
supported by research funding from the National Natural Science Foundation of China(82141130,82372735);the Sichuan Province Science and Technology Support Program(2019YJ0724,2023NSFSC1519);the China Postdoctoral Science Foundation(2022M712240);West China School/Hospital of Stomatology,Sichuan University(RCDWJS2022-10).
Head and neck squamous cell carcinoma(HNSCC)is the sixth most common malignant tumor worldwide.Considering its special anatomical site and the progressive resistance to chemotherapy drugs,the development of more effec...
supported by the Scientific Research Fund of the National Health Commission-Zhejiang Provincial Health Major Science and Technology Plan Project(No.WKJ-ZJ-2415);the Key Research and Development Program of Zhejiang Province(No.2024C03166);the Traditional Chinese Medicine Science and Technology Project of Zhejiang Province(No.2022ZB020);the Zhejiang Provincial Natural Science Foundation of China(No.LY21H160049).
Numerous studies have demonstrated that the high expression of CXC motif chemokine ligand 16(CXCL16)in cancer correlates with poor prognosis,as well as tumor cell proliferation,migration,and invasion.While CXCL16 can ...
supported by grants from the GuangDong Basic and Applied Basic Research Foundation(No.2023A1515030121,No.2021A1515111020,No.2023A1515010246);the National Natural Science Foundation of China(No.82273148,No.82103555,No.82301086);the Science and Technology Projects in Guangzhou(No.202206080009)。
Metabolic heterogeneity plays a central role in sustaining uncontrolled cancer cell proliferation and shaping the tumor microenvironment(TME),which significantly compromises the clinical outcomes and responses to ther...
supported by the National Natural Science Foundation of China(No.82160386);the Guangxi Natural Science Foundation of China(No.2024GXNSFDA010032,2023GXNSFAA026189).
Background:Head and neck squamous cell carcinoma(HNSCC)is a prevalent form of cancer globally,with chemoresistance posing a major challenge in treatment outcomes.The efficacy of the commonly used chemotherapeutic agent...
The authors regret that a mistake occurred during the presentation of Fig.5A,in which the result of 0.1μmol/L CA-4 group appeared incorrectly when merging different imaging pictures into one.This correction does not ...
supported by grants from the National Natural Science Foundation of China(82173362);China Postdoctoral Science Foundation(2022M720175,2023M734003);National Science Foundation of China(82304069).
Head and neck squamous cell carcinoma(HNSCC)is characterized by high recurrence or distant metastases rate and the prognosis is challenging.There is mounting evidence that tumor-infiltrating B cells(TIL-Bs)have a cruc...
the Taishan Scholar Project(No.ts20190991);the Key R&D Project of Shandong Province(2022CXPT023)。
Background:Traditional Chinese medicine is promising for managing challenging and complex disorders,including cancer,and in particular,saffron is applied in treating various cancer types.However,its potential therapeu...
supported by the National Natural Science Foundation of China(U21A20382).
Drug resistance in tumors constitutes a significant obstacle to tumor therapy.Head and neck squamous cell carcinoma(HNSCC)presents a major challenge due to its deep anatomical location,limited space,and complex struct...