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Anti-fatigue activity and mechanism of crocetin loaded nanoliposome in acute exercise-treated mice: 《Food Science and Human Wellness》2024年第6期3361-3370,共10页Jian Nan Jinglei Li Haishan Wu Haoran Cheng Hyun Jin Park Qingsheng Zhao Liu Yang; supported by National Natural Science Foundation of China(31700015);Health Commission of Hunan Province(C202306017634);Changsha Natural Science Foundation(KQ2208092).; Crocetin displays strong antioxidant,anti-inflammatory and anti-depression activity which is promising to relieve symptoms of fatigue.As a carotenoid,crocetin is difficult to dissolve in water and highly unstable agai...; 关键词：CROCETIN Nanoliposome Fatigue AMPK/PGC-1αpathway Gut microbiota

Inhibitory effect of saffron on head and neck squamous cell carcinoma via targeting of ESR1 and CCND1 by its active compound crocetin被引量：1: 《Traditional Medicine Research》2024年第7期25-34,共10页Xiao-Jie Wang Ming-Jun Zhang Li-Mei Cui Zhe-Ying Song Ya-Qi Wang Yu-Teng Yang Xiang-Kun Zhao Ya-Kui Mou Yu-Mei Li Xi-Cheng Song; the Taishan Scholar Project(No.ts20190991);the Key R&D Project of Shandong Province(2022CXPT023)。; Background:Traditional Chinese medicine is promising for managing challenging and complex disorders,including cancer,and in particular,saffron is applied in treating various cancer types.However,its potential therapeu...; 关键词：SAFFRON hub genes CROCETIN network pharmacology analysis HNSCC ESR1 CCND1

Crocetin protects cardiomyocytes against hypoxia/reoxygenation injury by attenuating Drp1-mediated mitochondrial fission via PGC-1α被引量：2: 《Journal of Geriatric Cardiology》2023年第1期68-82,共15页You-Ling MOU Rui ZHAO Shi-Ying LYU Zi-Yi ZHANG Mei-Fei ZHU Qian LIU; supported by the grants from National Natural Science Foundation of China(No.81903830);the Natural Science Foundation of Zhejiang Province(No.LY21H280005);the Research Project of Zhejiang Chinese Medical University(No.2021JKZK TS023B);the 2021 Innovation and Entrepreneurship Training Program for College Students(No.S202110344009).; BACKGROUND Saffron(Crocus sativus L.)has been traditionally used as food,spice,and medicine.Crocetin(CRT),as main bioactive component of saffron,has accumulated pieces of beneficial evidence on myocardial ischemia/rep...; 关键词：Drp1 INJURY traditionally

Mechanisms of saffron in treatment of atherosclerosis based on network pharmacology: 《Journal of Hainan Medical University》2021年第12期32-37,共6页Jing Yang Xing Ren Wan-Tong Zhang Rui Gao; Modernization of traditional Chinese medicine of national key research plan(No.2019YFC1709300);National major new drug development project(No.2017ZX09304003)。; Objective:To explore the main pathways and possible mechanisms of saffron anti-atherosclerosis(AS)using network pharmacology.Methods:The active ingredients and target proteins of the drug were obtained from the TCMSP ...; 关键词：SAFFRON Network pharmacology ATHEROSCLEROSIS CROCETIN ISORHAMNETIN QUERCETIN

Beneficial effects of saffron(Crocus sativus L.) in ocular pathologies, particularly neurodegenerative retinal diseases被引量：9: 《Neural Regeneration Research》2020年第8期1408-1416,共9页Jose A.Fernandez-Albarral Rosa de Hoz Ana I.Ramirez Ines Lopez-Cuenca Elena Salobrar-Garcia Maria D.Pinazo-Duran Jose M.Ramirez Juan J.Salazar; the Ophthalmological Network OFTARED(RD16/0008/0005,RD16/0008/0022, of the Institute of Health of Carlos III of the Spanish Ministry of Economy;by the PN I+D+i 2008–2011;by the ISCIII-Subdireccion General de Redes y Centros de Investigacion Cooperativa;by the European program FEDER.SAF-2014-53779-R:from the Spanish Ministry of Economy and Competitiveness;by Articulo 83 118-2017(UCM-Pharmactive Biotech);supported by a Predoctoral Fellowship(FPU17/01023)from the Spanish Ministry of Science,Innovation,and Universities;supported by a Predoctoral Fellowship(CT42/18-CT43/18)from the Complutense University of Madrid; Saffron(Crocus sativus L.)has been traditionally used in food preparation and as a medicinal plant.It currently has numerous therapeutic properties attributed to it,such as protection against ischemia,as well as antic...; 关键词：AMD CROCETIN CROCIN Crocus sativus L. diabetic retinopathy glaucoma neuroprotection ocular diseases retinitis pigmentosa SAFFRON SAFRANAL

Crocetin Potentiates Neurite Growth in Hippocampal Neurons and Facilitates Functional Recovery in Rats with Spinal Cord Injury被引量：7: 《Neuroscience Bulletin》2017年第6期695-702,共8页Xiqian Wang Xiejia Jiao Zhonghao Liu Yixin Li; Crocetin is an ingredient of traditional Chinese medicine and has therapeutic potential in various diseases due to its pharmacological properties, such as neuroprotection, anti-oxidative stress, and anti-inflammation....; 关键词：Crocetin Spinal cord injury Hippocampal neurons Inflammation

Crocetin Prevents Amyloid <i>β</i><sub>1-42</sub>-Induced Cell Death in Murine Hippocampal Cells被引量：1: 《Pharmacology & Pharmacy》2014年第1期37-42,共6页Yuta Yoshino Mitsue Ishisaka Naofumi Umigai Masamitsu Shimazawa Kazuhiro Tsuruma Hideaki Hara; Crocetin is an aglycon of carotenoid extracted by saffron stigmas (Crocus sativus L.) and known to have a potent anti-oxidative effect. Amyliod β (Aβ), hallmark of Alzheimer’s disease, is reported to have neurotoxi...; 关键词：Alzheimer’s Disease AMYLOID β1-42 CROCETIN HT22 Oxidative Stress

Crocetin induces cytotoxicity and enhances vincristine-induced cancer cell death via p53- dependent and ,independent mechanisms被引量：4: 《Acta Pharmacologica Sinica》2011年第12期1529-1536,共8页Ying-jia ZHONG Fang SHI Xue-lian ZHENG Qiong WANG Lan YANG Hong SUN Fan HE Lin ZHANG Yong LIN Yong QIN Lin-chuan LIAO Xia WANG; This study was supported in part by grants from the National Natural Science Foundation of China （No 30772539 and 30973403）, the Young Scientist Fund of Science ＆ Technology Department of Sichuan Province in China （2010JQ0012）, the Scientific Research Foundation for the Returned Overseas Chinese Scholar at the State Education Ministry of China, the Program for Changjiang Scholars and the Innovative Research Team in University （IRT0935）.; Aim： To investigate the anticancer effect of crocetin, a major ingredient in saffron, and its underlying mechanisms. Methods： Cervical cancer cell line HeLa, non-small cell lung cancer cell line A549 and ovarian can...; 关键词：CROCETIN VINCRISTINE cell cycle apoptosis P53 NEOPLASM

Crocin Synthesis Mechanism in Crocus sativus被引量：1: 《Tsinghua Science and Technology》2005年第5期567-572,共6页杨波郭志刚刘瑞芝; Saffron （Crocus sativus） cells can synthesize crocin, crocetin digentiobiosyl ester, in suspension cultures. The crocin family biosynthesis mechanism was studied using high pressure liquid chromatography （HPLC） to...; 关键词：SAFFRON CROCETIN crocetin di-neapolitanosyl ester GLUCOSYLTRANSFERASE GLYCOSYLATION

Effects of Crocetin on protecting DNA Against Oxidative Damages Induced by Free Radical Generation Systems被引量：10: 《中国药科大学学报》2002年第6期505-509,共5页刘同征陆宇等; 关键词：西红花酸过氧化氢 DNA碱基自由基发生系统损伤保护

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