ISORHAMNETIN

作品数：13被引量：41H指数：4
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相关机构：沈阳药科大学三峡大学第一临床医学院更多>>
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Effects of ginkgo flavone aglycone on atherosclerosis based on network pharmacology,molecular docking,and in vitro experiments被引量：1
《TMR Modern Herbal Medicine》2024年第2期1-10,共10页Miao Zhou Rui Li Qin Li Yan-Li Huang Shi-Jing Liu Ji-Yu Chen Yan He 
supported by the Science and Technology Foundation of Basic Research Program of Guizhou Province([2023]General 371,[2020]1Y381);the Administration of Traditional Chinese Medicine of Guizhou Province(QZYY-2018-130);the project of Key Laboratory of Basic Pharmacology of Ministry of Education,Zunyi Medicial University(No.qianjiaoheKYzi[2022]395);the Cultivation Plan of the NSFC(National Natural Science Foundation of China)of the affiliated hospital of Guizhou Medical University(GYFYNSFC-2021-55,GYFYNSFC-2021-56);the Cultivation Plan of the NSFC(National Natural Science Foundation of China)of Guizhou Medical University(21NSFCP13);the Science and Technology Foundation of Health Commission of Guizhou Province(gzwkj 2022-221).
Background:Ginkgo flavone aglycones(GA),a Ginkgo(Ginkgo biloba)extract,has been proven to have good biological activity in atherosclerosis(AS)treatment.Moreover,its active compounds and the corresponding mechanism for...
关键词：network pharmacology ginkgo flavone aglycones ATHEROSCLEROSIS molecular docking KAEMPFEROL QUERCETIN ISORHAMNETIN 
Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway被引量：3
《Chinese Journal of Integrative Medicine》2024年第4期299-310,共12页LIU Xiao-rong LI Shuo-fu MEI Wen-ya LIU Xiang-dan ZHOU Ri-bao 
Supported by the Natural Science Foundation of Hunan Province(Nos.2022JJ80086 and 2023JJ60342);the Project of Hunan Provincial Health and Health Commission(No.D202302078705);the Project of Hunan Provincial Student Innovation and Entrepreneurship Training Program(No.2022-5313);the Hunan Provincial Administration of Traditional Chinese Medicine Scientific Research Program(No.2021161);the Hunan University of Traditional Chinese Medicine Primary Discipline Open Fund Project in Chinese Medicine(No.2020ZYX01);the Key Discipline Project on Chinese Pharmacology of Hunan University of Chinese Medicine(No.202302);the Scientific Research Project of Hunan Provincial Administration of Traditional Chinese Medicine(No.B2023150)。
Objective To investigate the effect of isorhamnetin on the pathology of rheumatoid arthritis(RA).Methods Tumor necrosis factor(TNF)-α-induced fibroblast-like synoviocytes(FLS)was exposed to additional isorhamnetin(10...
关键词：rheumatoid arthritis ISORHAMNETIN SRC/ERK/CREB matrix metalloproteinase 
Targeting colorectal cancer using dietary flavonols
《Cancer Innovation》2024年第1期124-132,共9页Nitin Dubey Nidhi Dubey Upendra Bhadoria Kamal Shah Nagendra Singh Chauhan 
Colorectal cancer is among the well-known forms of cancer and a prominent cause of cancer demises worldwide.In vitro experiments reinforced by animal studies,as well as epidemiological studies of human colorectal canc...
关键词：ISORHAMNETIN KAEMPFEROL MYRICETIN QUERCETIN 
Isorhamnetin protects porcine oocytes from zearalenone-induced reproductive toxicity through the PI3K/Akt signaling pathway被引量：5
《Journal of Animal Science and Biotechnology》2023年第3期1054-1067,共14页Xiaoya Li Jiaxin Duan Shiyou Wang Jianyong Cheng Huali Chen Zelin Zhang Li Yang Rongmao Hua Qingwang Li 
supported Key Industry Innovation Chain of Shaanxi Province (2018ZDCXL-NY-02-06)。
Background Zearalenone(ZEA)widely exists in moldy grains,which seriously destroys the fertility of females.Isorhamnetin,a natural flavonoid,has extensive of pharmacological activities.However,the beneficial effect and...
关键词：Apoptosis ISORHAMNETIN OOCYTE Oxidative stress PORCINE ZEARALENONE 
Isorhamnetin protects zearalenone-induced damage via the PI3K/Akt signaling pathway in porcine ovarian granulosa cells被引量：3
《Animal Nutrition》2022年第4期381-390,共10页Xiaoya Li Huali Chen Zelin Zhang Jiaxin Duan Rongmao Hua Xiaodi Li Li Yang Jianyong Cheng Qingwang Li 
financially supported by Ministry of Agriculture Transgenic Major Projects(2018ZX0801013B);Key Industry Innovation Chain of Shaanxi Province(2018ZDCXL-NY-02-06)。
Zearalenone(ZEA)is widely derived from moldy cereal grain,which has adverse effects on animal reproduction.In particular,pigs are more sensitive to ZEA-induced toxicity than other animals.Isorhamnetin has extensive ph...
关键词：ZEARALENONE ISORHAMNETIN OVARIAN GRANULOSA cell Apoptosis Endoplasmic reticulum STRESS Oxidative STRESS 
苦参根中化学成分及其体外抗肿瘤活性研究被引量：8
《中草药》2022年第4期978-984,共7页龙国清 王东东 胡高升 魏江春 王安华 贾景明 
国家重点研发计划项目(2017YFC1701200);辽宁省“兴辽英才计划”项目(XLYC1902101)。
目的研究苦参Sophora flavescens根的化学成分及其体外抗肿瘤活性。方法利用大孔树脂柱色谱、硅胶柱色谱、ODS柱色谱及半制备型HPLC等进行分离纯化,结合理化性质及波谱数据鉴定化合物的结构;评估了从苦参根提取物中分离得到的11个化合...
关键词：苦参 抗肿瘤活性 苦参酮 异戊烯基黄酮 胡椒酸 丁香酸 8-(3 3-dimethylallyl)isorhamnetin 
Mechanisms of saffron in treatment of atherosclerosis based on network pharmacology
《Journal of Hainan Medical University》2021年第12期32-37,共6页Jing Yang Xing Ren Wan-Tong Zhang Rui Gao 
Modernization of traditional Chinese medicine of national key research plan(No.2019YFC1709300);National major new drug development project(No.2017ZX09304003)。
Objective:To explore the main pathways and possible mechanisms of saffron anti-atherosclerosis(AS)using network pharmacology.Methods:The active ingredients and target proteins of the drug were obtained from the TCMSP ...
关键词：SAFFRON Network pharmacology ATHEROSCLEROSIS CROCETIN ISORHAMNETIN QUERCETIN 
Umbilical cord-derived mesenchymal stem cells preconditioned with isorhamnetin:potential therapy for burn wounds被引量：3
《World Journal of Stem Cells》2020年第12期1652-1666,共15页Shazmeen Aslam Irfan Khan Fatima Jameel Midhat Batool Zaidi Asmat Salim 
BACKGROUND Impaired wound healing can be associated with different pathological states.Burn wounds are the most common and detrimental injuries and remain a major health issue worldwide.Mesenchymal stem cells(MSCs)pos...
关键词：Burn wound ISORHAMNETIN Mesenchymal stem cells PRECONDITIONING Wound healing Small molecule 
Effect of Different Isorhamnetin of Different Density Cultured Rat C6 Glioma Cells in Vitro
《Proceedings of Anticancer Research》2018年第1期33-44,共12页Yang Jinhua Sun Zhuanni Yang Xiangli Tian Ruirui 
Objective To explore the influence of different concentrations of isorhamnetin on C6 glioma cell morphology.Methods Set the blank control group,blank solvent control group and reagent group of four concentration,the g...
关键词：ISORHAMNETIN C6 GLIOMA cells Cell apoptosis PI3K/AKT PATHWAY 
An UHPLC-MS/MS method for simultaneous determination of quercetin 3-O-rutinoside, kaempferol 3-O-rutinoside, isorhamnetin 3-O-rutinoside, bilobalide and ligustrazine in rat plasma, and its application to pharmacokinetic study of Xingxiong injection被引量：6
《Chinese Journal of Natural Medicines》2017年第9期710-720,共11页DOU Li-Li DUAN Li GUO Long LIU Le-Le ZHANG Yu-Dong LI Ping LIU E-Hu 
financially supported from National Natural Science Foundation of China(Nos.81673569,and 81473343);Program for New Century Excellent Talents in University(No.NECT-13-1034);a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions
The present study was designed to develop and validate a rapid, sensitive, and reliable ultra-high performance liquid chromatography coupled with tandem mass spectrometry(UHPLC-MS/MS) method for the simultaneous deter...
关键词：UHPLC-MS/MS Xingxiong injection Pharmacokinetics Rat plasma 
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