Beneficial effects of saffron(Crocus sativus L.) in ocular pathologies, particularly neurodegenerative retinal diseases  

作　　者：Jose A.Fernandez-Albarral Rosa de Hoz Ana I.Ramirez Ines Lopez-Cuenca Elena Salobrar-Garcia Maria D.Pinazo-Duran Jose M.Ramirez Juan J.Salazar 

机构地区：[1]Instituto de Investigaciones Oftalmologicas Ramon Castroviejo,Madrid,Spain [2]Departamento de Inmunologia,Oftalmologia y ORL,Facultad de Optica y Optometria,Madrid,Spain [3]Departamento de Inmunologia,Oftalmologia y ORL,Facultad de Medicina,Madrid,Spain [4]Unidad de Investigacion Oftalmologica Santiago Grisolia,Universidad de Valencia,Valencia,Spain

出　　处：《Neural Regeneration Research》2020年第8期1408-1416,共9页中国神经再生研究（英文版）

基　　金：the Ophthalmological Network OFTARED(RD16/0008/0005,RD16/0008/0022, of the Institute of Health of Carlos III of the Spanish Ministry of Economy;by the PN I+D+i 2008–2011;by the ISCIII-Subdireccion General de Redes y Centros de Investigacion Cooperativa;by the European program FEDER.SAF-2014-53779-R:from the Spanish Ministry of Economy and Competitiveness;by Articulo 83 118-2017(UCM-Pharmactive Biotech);supported by a Predoctoral Fellowship(FPU17/01023)from the Spanish Ministry of Science,Innovation,and Universities;supported by a Predoctoral Fellowship(CT42/18-CT43/18)from the Complutense University of Madrid

摘　　要：Saffron(Crocus sativus L.)has been traditionally used in food preparation and as a medicinal plant.It currently has numerous therapeutic properties attributed to it,such as protection against ischemia,as well as anticonvulsant,antidepressant,anxiolytic,hypolipidemic,anti-atherogenic,anti-hypertensive,antidiabetic,and anti-cancer properties.In addition,saffron has remarkable beneficial properties,such as anti-apoptotic,anti-inflammatory and antioxidant activities,due to its main metabolites,among which crocin and crocetin stand out.Furthermore,increasing evidence underwrites the possible neuroprotective role of the main bioactive saffron constituents in neurodegenerative diseases,such as Parkinson’s and Alzheimer’s diseases,both in experimental models and in clinical studies in patients.Currently,saffron supplementation is being tested for ocular neurodegenerative pathologies,such as diabetic retinopathy,retinitis pigmentosa,age-related macular degeneration and glaucoma,among others,and shows beneficial effects.The present article provides a comprehensive and up to date report of the investigations on the beneficial effects of saffron extracts on the main neurodegenerative ocular pathologies and other ocular diseases.This review showed that saffron extracts could be considered promising therapeutic agents to help in the treatment of ocular neurodegenerative diseases.Saffron(Crocus sativus L.) has been traditionally used in food preparation and as a medicinal plant. It currently has numerous therapeutic properties attributed to it, such as protection against ischemia, as well as anticonvulsant, antidepressant, anxiolytic, hypolipidemic, anti-atherogenic, anti-hypertensive, antidiabetic, and anti-cancer properties. In addition, saffron has remarkable beneficial properties, such as anti-apoptotic, anti-inflammatory and antioxidant activities, due to its main metabolites, among which crocin and crocetin stand out. Furthermore, increasing evidence underwrites the possible neuroprotective role of the main bioactive saffron constituents in neurodegenerative diseases, such as Parkinson’s and Alzheimer’s diseases, both in experimental models and in clinical studies in patients. Currently, saffron supplementation is being tested for ocular neurodegenerative pathologies, such as diabetic retinopathy, retinitis pigmentosa, age-related macular degeneration and glaucoma, among others, and shows beneficial effects. The present article provides a comprehensive and up to date report of the investigations on the beneficial effects of saffron extracts on the main neurodegenerative ocular pathologies and other ocular diseases. This review showed that saffron extracts could be considered promising therapeutic agents to help in the treatment of ocular neurodegenerative diseases.

关 键 词：AMD CROCETIN CROCIN Crocus sativus L. diabetic retinopathy glaucoma neuroprotection ocular diseases retinitis pigmentosa SAFFRON SAFRANAL 

分 类 号：R74[医药卫生—神经病学与精神病学]