Spectral computed tomography-guided photothermal therapy of osteosarcoma by bismuth sulfide nanorods  

作　　者：Yuhan Li Xiaoxue Tan Han Wang Xiuru Ji Zi Fu Kai Zhang Weijie Su Jian Zhang Dalong Ni 

机构地区：[1]School of Medicine,Shanghai University,No.99 Shangda Rd,Shanghai 200444,China [2]Shanghai University,Shanghai Universal Medical Imaging Diagnostic Center,Bldg 8,No.406 Guilin Rd,Shanghai 200233,China [3]Department of Orthopaedics,Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases,Shanghai Institute of Traumatology and Orthopaedics,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,No.197,Ruijin 2nd Rd,Shanghai 200025,China [4]Department of Plastic and Reconstructive Surgery,Shanghai Ninth People’s Hospital,Shanghai JiaoTong University School of Medicine,No.639,Zhizaoju Rd.Shanghai 200011,China

出　　处：《Nano Research》2023年第7期9885-9893,共9页纳米研究（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(No.82102190);the Foundation of National Facility for Translational Medicine(Shanghai)(No.TMSK-2021-122);Shanghai Municipal Health Commission Research Project(No.201840082);The animal study protocol was approved by the Institutional Animal Care and Use Committee at Shanghai JiaoTong University。

摘　　要：Osteosarcoma(OS)is the most normally primary malignant bone cancer in adolescents.Due to their analogous X-ray attenuation properties,healthy bones and malignancies with iodine enhancement cannot be distinguished by conventional computed tomography(CT).As one kind of spectral CT,dual-energy CT(DECT)offers multiple functions for material separation and cancer treatments.Herein,bismuth sulfide(Bi_(2)S_(3))nanorods(NRs)were synthesized as special contrast agents(CAs)for DECT,which have superior imaging properties than clinical iodine CAs.At the same time,the high photothermal conversion rates of Bi_(2)S_(3)NRs can be used for DECT-guided photothermal therapy(PTT)to destroy OS and inhibit tumor growth under the guidance of DECT imaging.Importantly,DECT imaging real-timely monitored that PTT could accelerate the diffusion of Bi2S3 NRs in the tumor,obtaining detailed information on the internal distribution of nanomaterials in tumors around the bone to avoid injury to normal tissues by PTT.Overall,the proposed strategy of DECT imaging-guided PTT appears enormous promise for bone disease treatment.

关 键 词：dual-energy computed tomography NANOMEDICINE bismuth sulfide photothermal therapy OSTEOSARCOMA 

分 类 号：R730.5[医药卫生—肿瘤]