A Randomized Controlled Trial of Mindfulness in Recovery from Colorectal Cancer  

作　　者：Andrew McCombie Jennifer Jordan Roger Mulder Kishion Dee Ee Lin Ong Fernanda Fernandez Zimmermann Chris Frampton Frank Frizelle 

机构地区：[1]Te Whatu Ora(Health New Zealand)Waitaha Canterbury,Christchurch 8011,New Zealand [2]University of Otago,Christchurch 8140,New Zealand [3]The Psychology Hub,Christchurch 8011,New Zealand [4]Oxford Mindfulness Centre,University of Oxford,Oxford,OX12JD,United Kingdom [5]Nature and Nurture Sparks,Christchurch 8013,New Zealand [6]University of Otago,Dunedin(9016),New Zealand

出　　处：《Chinese Journal of Integrative Medicine》2023年第7期590-599,共10页中国结合医学杂志（英文版）

摘　　要：Objective:This study examined whether a 4-week group-based mindfulness intervention would be superior in reducing psychological distress in colorectal cancer(CRC)patients compared to a psychoeducation and cognitive behavioural skills learning support active control group.Methods:Patients with CRC were randomized via Computerised Permuted Block Randomisation to mindfulness or active control groups(2-h weekly sessions over 4 weeks).Outcomes were measured pre-intervention,and 8 weeks and 6 months post-baseline.The primary outcome was psychological distress measured by the Hospital Anxiety and Depression Scale.Secondary outcomes were generic quality of life(QoL),disease specific QoL,mindfulness,and intervention credibility and acceptability.Results:Sixty-eight participants were randomized to mindfulness(n=35)or active control group(n=33).Uptake of potentially eligible patients consenting was low(28.0%)and the dropout rate was 33.8%.Depression scores were reduced in both groups at week 8(P=0.020).Control participants had greater improvement in generic mental QoL scores at week 8 than mindfulness(P=0.023).In disease specific QoL,there was reduction in impotence symptom in the mindfulness group(P=0.022)and reduction in faecal incontinence in the control group(P=0.019).The embarrassment symptom had a significantly lower increase in the mindfulness group at week 8 compared to the control group(P=0.009).Both groups rated the treatments as credible and acceptable.Conclusions:Mindfulness was not superior to the active control group in terms of alleviating psychological distress but both treatments were associated with some improvements in depression.There was low uptake of both interventions.(Trial registration number:ACTRN12616001033437)

关 键 词：ANXIETY colorectal cancer depression DISTRESS MINDFULNESS PSYCHOEDUCATION PSYCHOLOGY psychological distress randomized controlled trial quality of life 

分 类 号：R735.34[医药卫生—肿瘤]