Weakened humoral and cellular immune response to the inactivated COVID-19 vaccines in Chinese individuals with obesity/overweight  

作　　者：Qian Zhu Yingzhi Zhang Juan Kang Zhiwei Chen Mingli Peng Min Chen Gaoli Zhang Dejuan Xiang Shuang Xiao Hu Li Ying Mei Jie Yang Xiaoya Qi Dachuan Cai Hong Ren 

机构地区：[1]Department of Infectious Diseases,Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education),Institute for Viral Hepatitis,The Second Affiliated Hospital,Chongqing Medical University,Chongqing 400061,China [2]Health Management Center,The Second Affiliated Hospital of Chongqing Medical University,Chongqing 400061,China

出　　处：《Genes & Diseases》2023年第2期608-617,共10页基因与疾病（英文）

基　　金：supported by the National Science and Technology Major Project of China(No.2017ZX10202203-007,No.2017ZX10202203-008,and No.2018ZX10302206-003);a pilot project of clinical cooperation between traditional Chinese and western medicine for significant and complicated diseases of National Administration of Traditional Chinese Medicine:hepatic fibrosis.We also acknowledge the support of the National Natural Science Foundation of China(No.81772198);the Natural Science Foundation of Chongqing,China(No.cstc2020jcyj-msxmX0389);General Project of Chongqing Natural Science Foundation(No.cstc2020jcyj-msxmX0015).

摘　　要：Inactivated COVID-19 vaccines have been widely used to vaccinate the Chinese population.However,limited literature exists to explore the effect of obesity on the humoral and cellular immune response to these vaccines.In this study,132 high BMI(Body mass index)(obesity and overweight,BMI≥24 kg/m^(2))and 82 normal BMI(BMI<24 kg/m^(2))participants were enrolled.Adverse events(AEs),Spike receptor-binding domain IgG antibody(anti-RBD-IgG),neutralizing antibodies(NAbs),and specific B-cell and T-cell responses were evaluated 21–105 days after full-course inactivated COVID-19 vaccination.The overall incidence of AEs was similar in individuals with and without obesity/overweight.No serious vaccine-related AEs occurred.Individuals with obesity/overweight had a reduced seropositivity rate of NAbs compared to those with normal BMI.Anti-RBD-IgG and NAbs titers in the high BMI group were significantly lower than those in the normal BMI group.The frequencies of RBD-specific memory B cells(MBCs)and the numbers of spike-specific TNF-α+spot-forming cells(SFCs)in individuals with obesity/overweight were reduced compared with those noted in individuals without obesity/overweight.A similar trend of weakened humoral responses was also observed in individuals with central obesity.Our study results suggested that inactivated COVID-19 vaccines were safe and well tolerated but induced poor humoral and cellular immune responses in Chinese individuals with obesity/overweight.

关 键 词：COVID-19 Immune response Inactivated vaccine OBESITY OVERWEIGHT 

分 类 号：R575.5[医药卫生—消化系统]