Effect of levetiracetam and valproate on late‑onset post‑traumatic seizures  

作　　者：Yanli Wang Yiqi Wang Huifang Wang Xiaoping Du Jie Miao James X.Tao Meizhen Sun 

机构地区：[1]Department of Rehabilitation,Shanxi Traditional Chinese Medical Hospital,Taiyuan 030012,China [2]Department of Neurology,The First Hospital of Shanxi Medical University,Taiyuan 030012,China [3]Department of Neurology,University of Chicago,Chicago,IL 60601,USA

出　　处：《Acta Epileptologica》2023年第2期86-89,共4页癫痫学报（英文）

基　　金：funded by the Scientific Research Fund of China Association Against Epilepsy(No 2012002).

摘　　要：Background To compare the preventive effects of levetiracetam and valproate on late-onset post-traumatic seizures in patients with traumatic brain injury(TBI).Methods A total of 95 patients with TBI were recruited from 2017 to 2020.They were randomized into three groups:levetiracetam(LEV)group(n=30)receiving LEV treatment(500 mg,bid,po);valproate group(n=32)receiving sodium valproate(500 mg/d,once daily,po);and control group(n=33)receiving no anti-seizure medication.LEV and valproate were given to corresponding groups within seven days after TBI,and the administration lasted for one month.The incidence of epilepsy and adverse events were evaluated at 7 days and 12 months post-TBI.Results The cumulative incidences of late post-traumatic seizures at the 12-month follow-up in the LEV,valproate,and control groups were 3.33%,12.50%and 15.63%,respectively.The cumulative incidence of late post-traumatic seizures in the LEV group was significantly lower than those in the valproate and control groups(P<0.05).The cumulative incidence of late post-traumatic seizure in the valproate group was not significantly different from that in the control group(P>0.05).Conclusions LEV can reduce the cumulative incidence of late post-traumatic seizures,whereas valproate can not.

关 键 词：LEVETIRACETAM Valproate Post-traumatic seizure 

分 类 号：R742.1[医药卫生—神经病学与精神病学]