儿童身材矮小与眼部生物学参数的相关性分析  

Correlation analysis between short stature and ocular biological parameters in children

作　　者：王月 朱如源 封利霞[1] 刘晓静[2] Wang Yue;Zhu Ruyuan;Feng Lixia;Liu Xiaojing(Dept of Ophthalmology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022;Dept of Pediatrics,The First Affiliated Hospital of Anhui Medical University,Hefei 230022)

机构地区：[1]安徽医科大学第一附属医院眼科,合肥230022 [2]安徽医科大学第一附属医院儿科,合肥230022

出　　处：《安徽医科大学学报》2023年第7期1217-1221,共5页Acta Universitatis Medicinalis Anhui

基　　金：中华国际医学交流基金会儿科内分泌中青年医师成长研基金(编号:Z-2019-41-2101-01)。

摘　　要：目的研究儿童身材矮小与眼部生物学参数之间的相关性。方法采用横断面研究方法,纳入身高低于第十百分数值且视力正常的儿童82例82眼作为矮小组,另选取年龄、性别匹配的健康儿童130例130眼作为对照组。所有受试者进行眼部生物学参数测量,包括视力、眼轴、角膜曲率、角膜散光、眼压、角膜中央厚度、前房深度、晶体厚度以及白到白距离,并计算轴率比。分析两组间眼部生物学参数的差异,以及身高与参数之间的相关性。结果眼部生物学参数测量结果显示,矮小组眼轴小于对照组,差异有统计学意义(t=-3.161,P=0.002);两组角膜曲率、前房深度差异均有统计学意义(t=2.996、t=-2.449,P<0.05),其中矮小组角膜曲率大于对照组,前房深度小于对照组;其他眼部生物学参数比较差异无统计学意义(P>0.05)。矮小组中男性眼轴(t=-2.435,P=0.015)、轴率比(t=2.577,P=0.012)、前房深度(t=2.563,P=0.012)高于女性,差异有统计学意义。两组眼轴、轴率比、眼压、前房深度均与年龄、身高呈正相关,晶体厚度与年龄、身高呈负相关。在控制年龄和性别后,矮小组眼轴和轴率比与身高呈正相关,与年龄无相关性。结论矮小儿童的眼部生物学参数与正常儿童之间存在差异,提示一方面矮小儿童家长应该尽早关注孩子的眼部发育状况;另一方面在进行儿童眼部筛查时,针对身材矮小儿童应该有不同的筛查标准;未来还需要纳入更多、更全面的研究以补充这方面的数据。Objective To study the correlation between short stature and ocular biological parameters in children.Methods This study adopted a cross-sectional study.Eighty-two children(82 eyes)with height lower than the tenth percentage and normal vision were selected as the short group.One hundred and thirty healthy children(130 eyes)with age and sex matching were served as the control group.Ocular biological parameters were measured for all subjects,including visual acuity,axial length,corneal curvature,astigmatism,intraocular pressure,central corneal thickness,anterior chamber depth,lens thickness and the distance of whiteness to whiteness.Then axial length/corneal radius ratio was calculated.The dfferences in ocular biological parameters between the two groups and the correlation between height and parameters were analyzed.Results The measurement of ocular biological parameters showed that the axial length of the short group was lower than that of the control group,and the difference was statistically significant(t=-3.161,P=0.002).Also there were significant differences in corneal curvature,anterior chamber depth between the two groups(t=2.996,-2.449,P<0.05).The corneal curvature of the short group was greater than that of the control group,and the anterior chamber depth of the short group was smaller than that of the control group.There were no significant differences in other ocular biological parameters(P>0.05).In the short group,axial length(t=-2.435,P=0.015),axial length/corneal radius ratio(t=2.577,P=0.012)and anterior chamber depth(t=2.563,P=0.012)of male were higher than those of female,and the difference was statistically significant.Axial length,axial length/corneal radius ratio,intraocular pressure,and anterior chamber depth were positively correlated with age and height,and lens thickness was negatively correlated with age and height.After controlling for age and sex,axial length and axial length/corneal radius ratio were positively associated with height and no correlation with age.Conclusion There are diffe

关 键 词：身材矮小 儿童 眼轴 眼部生物学参数 轴率比 

分 类 号：R778[医药卫生—眼科] R179[医药卫生—临床医学]