癫痫发作史与ASMs用药史对脑胶质瘤患者术前认知功能、情绪障碍的影响  

Influence of history of epileptic seizures and use of ASMs on preoperative cognitive function and emo tional disorders in patients with glioma

作　　者：杨继学 王向辉 李东明 王迎兵 董燕[1] 王海艳[1] YANG Jixue;WANG Xianghui;LI Dongming(Department of Neurosurgery,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第三附属医院神经外科,郑州450052

出　　处：《国际精神病学杂志》2023年第3期491-494,共4页Journal Of International Psychiatry

基　　金：河南省医学科技攻关计划联合共建项目(编号:LHGJ20190373)。

摘　　要：目的探讨术前癫痫发作史与抗癫痫药物(ASMs)用药史对脑胶质瘤患者术前认知功能、情绪障碍的影响。方法回顾性分析2016年6月~2020年6月本院收治的96例脑胶质瘤患者的临床资料,根据患者癫痫发作和用药情况分为A组(存在癫痫发作史且有ASMs用药史,n=33)、B组(存在癫痫发作史但无ASMs用药史,n=21)和C组(无癫痫发作史且无ASMs用药史,n=42),另选择同期于本院接受体检的健康体检者35例为对照组。比较各组一般临床资料、认知功能、焦虑和抑郁情绪状态。结果A组Rivermead行为记忆测验(RBMT)评分、倒数N项测验(N-back)任务准确率低于B组、C组和对照组(P<0.05);B组N-back任务准确率低于对照组(P<0.05)。A组、B组的数字连线测验A、B完成时间长于C组、对照组(P<0.05),数字符号测验和言语流畅性测验评分低于C组、对照组(P<0.05)。各组贝克抑郁量表(BDI-Ⅱ)、贝克焦虑量表(BAI)评分比较:A组>B组>C组>对照组(P<0.05)。结论癫痫发作史和ASMs用药史可能会增加脑胶质瘤患者术前记忆功能、执行功能受损的风险,诱发情绪障碍。Objective To explore the influence of history of epileptic seizures and use of anti-seizure medications(ASMs)on preoperative cognitive function and emotional disorders in patients with glioma.Methods The clinical data of 96 patients with glioma admitted to the hospital between June 2016 and June 2020 were retrospectively analyzed.According to the status of epileptic seizures and medication,the patients were divided into group A(with history of epileptic seizures and use of ASMs,n=33),group B(with history of epileptic seizures but without use of ASMs.n=21)and group C(without history of epileptic seizures or use of ASMs,n=42).Meanwhile,35 healthy individuals were selected as the control group.General clinical data,cognitive function,anxiety and depression were compared among the groups.Results The Rivermead behavioral memory test(RBMT)scores and accuracy rate of N-back task in group A were lower than those in the other three groups(P<0.05).The accuracy rate of N-back task in group B was lower than that in control group(P<0.05).The time to complete trail making test A and B in group A and group B was longer than that in group C and control group(P<0.05).The digit symbol test and language fluency test scores were lower than those of group C and control group(P<0.05).The Beck Depression Inventory II(BDI-II)scores and Beck Anxiety Inventory(BAI)scores decreased in order from group A,group B,group C to the control group(P<0.05).Conclusion History of epileptic seizures and use of ASMs may increase the risk of preoperative memory function and executive function damage in patients with glioma,and induce emotional disorders.

关 键 词：脑胶质瘤 癫痫 抗癫痫药物 记忆功能 执行功能 

分 类 号：R749[医药卫生—神经病学与精神病学]