咖啡摄入量与肝癌风险的剂量-反应Meta分析  

Association between coffee consumption and risk of liver cancer:a dose-response meta-analysis

作　　者：刘倩倩 严雪 詹柳艳 李瑶[1,2] 魏思琪 LIU Qianqian;YAN Xue;ZHAN Liuyan;LI Yao;WEI Siqi(School of Nursing,Lanzhou University,Lanzhou 730000,P.R.China;Evidence-Based Nursing Center,School of Nursing of Lanzhou University,Lanzhou 730000,P.R.China)

机构地区：[1]兰州大学护理学院,兰州730000 [2]兰州大学循证护理中心,兰州730000

出　　处：《中国循证医学杂志》2023年第7期814-819,共6页Chinese Journal of Evidence-based Medicine

基　　金：甘肃省教育厅科技创新项目(编号:2022CXZX-146);兰州大学双一流引流专项(编号:56112020)。

摘　　要：目的系统评价咖啡摄入量与肝癌发病风险的剂量-反应关系。方法计算机检索PubMed、Web of Science、Cochrane Library、EMbase、CNKI、VIP、WanFang Data和CBM数据库,搜集研究目的相关的队列研究和病例-对照研究,检索时限均从建库至2022年12月。由2位研究员独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Stata 17.0软件进行Meta分析。结果共纳入15项研究,包括11项队列研究和4项病例-对照研究,包括557259名研究对象。Meta分析结果表明:咖啡摄入量与肝癌风险降低显著相关[RR=0.39,95%CI(0.27,0.57),P<0.01],咖啡摄入量与肝癌风险之间存在非线性剂量-反应关系(P<0.01)。与不喝咖啡的人群相比,每天喝1杯咖啡的人群肝癌风险降低约25%[RR=0.75,95%CI(0.67,0.83)],喝2杯咖啡的人群肝癌风险降低约38%[RR=0.62,95%CI(0.56,0.70)],喝3杯咖啡的人群肝癌风险降低约45%[RR=0.55,95%CI(0.48,0.62)],喝4杯咖啡的人群肝癌风险降低约51%[RR=0.49,95%CI(0.43,0.56)]。结论当前有限证据表明,咖啡摄入量与肝癌风险呈负相关,且两者间存在非线性剂量-反应关系,提示习惯性饮用咖啡是肝癌发生的保护因素。受纳入研究数量和质量限制,上述结论尚需开展更多高质量研究予以验证。Objective To systematically evaluate the dose-response relationship between coffee consumption and liver cancer risk.Methods The PubMed,Web of Science,Cochrane Library,EMbase,CNKI,VIP,WanFang Data,and CBM databases were searched from inception to December 2022.Two reviewers independently screened literature,extracted data and assessed the risk of bias of the included studies.Meta-analysis was then performed by using Stata 17.0software.Results Fifteen studies(11 cohort studies and 4 case-control studies)involving 557259 participants were included.The results of meta-analysis showed that coffee consumption was significantly negatively associated with the risk of liver cancer(RR=0.39,95%CI 0.27 to 0.57,P0.01).The dose-response meta-analysis showed a non-linear doseresponse relationship between coffee consumption and the risk of liver cancer(P0.01).Compared with people who did not drink coffee,people who drank 1 cup of coffee a day had a 25%lower risk of liver cancer(RR=0.75,95%CI 0.67 to 0.83),and people who drank 2 cups of coffee a day had a 38%lower risk of liver cancer(RR=0.62,95%CI 0.56 to 0.70).The risk of liver cancer decreased by 45%(RR=0.55,95%CI 0.48 to 0.62)for 3 cups of coffee and by 51%(RR=0.49,95%CI 0.43to 0.56)for 4 cups of coffee.Conclusion Current evidence suggests that there is a nonlinear dose-response relationship between coffee consumption and the risk of liver cancer.These results indicate that habitual coffee consumption is a protective factor for liver cancer.Due to the limited quality and quantity of the included studies,more high quality studies are needed to verify the above conclusion.

关 键 词：咖啡 肝癌 META分析 剂量-反应关系 

分 类 号：R735.7[医药卫生—肿瘤]