Human retinal secretome:A cross-link between mesenchymal and retinal cells  

作　　者：Luigi Donato Concetta Scimone Simona Alibrandi Sergio Zaccaria Scalinci Domenico Mordà Carmela Rinaldi Rosalia D'Angelo Antonina Sidoti 

机构地区：[1]Department of Biomedical and Dental Sciences and Morphofunctional Imaging,University of Messina,Messina 98125,Italy [2]Department of Biomolecular Strategies,Genetics and Cutting-Edge Therapies,Euro-Mediterranean Institute of Science and Technology,Palermo 90139,Italy [3]Department of Chemical,Biological,Pharmaceutical and Environmental Sciences,University of Messina,Messina 98125,Italy [4]Department of Medical and Surgical Sciences,University of Bologna,Bologna 40121,Italy

出　　处：《World Journal of Stem Cells》2023年第7期665-686,共22页世界干细胞杂志（英文版）（电子版）

摘　　要：In recent years,mesenchymal stem cells(MSC)have been considered the most effective source for regenerative medicine,especially due to released soluble paracrine bioactive components and extracellular vesicles.These factors,collectively called the secretome,play crucial roles in immunomodulation and in improving survival and regeneration capabilities of injured tissue.Recently,there has been a growing interest in the secretome released by retinal cytotypes,especially retinal pigment epithelium and Müller glia cells.The latter trophic factors represent the key to preserving morphofunctional integrity of the retina,regulating biological pathways involved in survival,function and responding to injury.Furthermore,these factors can play a pivotal role in onset and progression of retinal diseases after damage of cell secretory function.In this review,we delineated the importance of cross-talk between MSCs and retinal cells,focusing on common/induced secreted factors,during experimental therapy for retinal diseases.The cross-link between the MSC and retinal cell secretomes suggests that the MSC secretome can modulate the retinal cell secretome and vice versa.For example,the MSC secretome can protect retinal cells from degeneration by reducing oxidative stress,autophagy and programmed cell death.Conversely,the retinal cell secretome can influence the MSC secretome by inducing changes in MSC gene expression and phenotype.

关 键 词：SECRETOME Mesenchymal stem cells Retinal cells Extracellular vesicles Retinal diseases 

分 类 号：R774.1[医药卫生—眼科]