Neural stem cells for Parkinson’s disease management:Challenges,nanobased support,and prospects  

作　　者：Tuba Oz Ajeet Kaushik Małgorzata Kujawska 

机构地区：[1]Department of Toxicology,Poznan University of Medical Sciences,Poznan 60-631,Poland [2]NanoBioTech Laboratory,Health System Engineering,Department of Environmental Engineering,Florida Polytechnic University,Lakeland,FL 33805,United States [3]School of Engineering,University of Petroleum and Energy Studies,Dehradun 248007,India

出　　处：《World Journal of Stem Cells》2023年第7期687-700,共14页世界干细胞杂志（英文版）（电子版）

基　　金：Supported by Narodowe Centrum Nauki,No.2021/42/E/NZ7/00246.

摘　　要：Parkinson’s disease(PD),characterized by loss of nigrostriatal dopaminergic neurons,is one of the most predominant neurodegenerative diseases affecting the elderly population worldwide.The concept of stem cell therapy in managing neurodegenerative diseases has evolved over the years and has recently rapidly progressed.Neural stem cells(NSCs)have a few key features,including selfrenewal,proliferation,and multipotency,which make them a promising agent targeting neurodegeneration.It is generally agreed that challenges for NSC-based therapy are present at every stage of the transplantation process,including preoperative cell preparation and quality control,perioperative procedures,and postoperative graft preservation,adherence,and overall therapy success.In this review,we provided a comprehensive,careful,and critical discussion of experimental and clinical data alongside the pros and cons of NSC-based therapy in PD.Given the state-of-the-art accomplishments of stem cell therapy,gene therapy,and nanotechnology,we shed light on the perspective of complementing the advantages of each process by developing nano-stem cell therapy,which is currently a research hotspot.Although various obstacles and challenges remain,nano-stem cell therapy holds promise to cure PD,however,continuous improvement and development from the stage of laboratory experiments to the clinical application are necessary.

关 键 词：Parkinson’s disease SYNUCLEIN Neural stem cells NANOMATERIALS Nano-stem cell therapy 

分 类 号：R742.5[医药卫生—神经病学与精神病学]